Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritis.
Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritis.
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DOI：
10.1016/j.ajo.2005.06.012
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发表时间：
2004-05
期刊：
影响因子：
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通讯作者：
S. Hickman;C. Wheeler-Kingshott;Stephen J. Jones;K. Miszkiel;G. Barker;G. Plant;David H. Miller
中科院分区：
文献类型：
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作者：
S. Hickman;C. Wheeler-Kingshott;Stephen J. Jones;K. Miszkiel;G. Barker;G. Plant;David H. Miller
背景和目的：扩散加权（DW）成像导致的表观扩散系数（ADC）增加被认为是由于轴突破坏所致，并且在多发性硬化症病变中已充分记录了这种变化。然而，视神经的 DW 成像面临许多挑战。本研究的目的是通过使用带状倾斜多截面回波平面成像来测量视神经炎患者的 ADC。 方法：使用扩散序列对 18 名 1 年前经历过视神经炎发作的患者和 11 名对照受试者的视神经进行成像（可用数据来自 16 名患者和 10 名对照受试者）。由盲人观察者使用计算机辅助基于阈值的轮廓技术对眼眶视神经进行分割，并确定平均 ADC。 结果：患病视神经的平均 ADC 为 1324 × 10−6mm2/s，而健康对侧视神经的平均 ADC 为 990 × 10−6mm2/s（与患病视神经相比，P= .005）和 928 ×来自对照视神经的 10−6mm2/s（与患病视神经相比，P= .006，与健康对侧视神经相比，P= .40）。患病视神经 ADC 与视觉（例如，rS= 0.73；logMAR 视力的 P= .001）和电生理参数（例如，视觉诱发电位中心场振幅 [VEP] 的 rS= -0.57，P= .021）相关。 结论：在患者群体中应用 DW 成像是可能的，并且在视神经炎后的慢性期，平均 ADC 与临床和电生理学参数的相关性表明 ADC 可以替代测量慢性炎症后视神经病变中的轴突破坏。
BACKGROUND AND PURPOSE:Increases in apparent diffusion coefficient (ADC) from diffusion-weighted (DW) imaging are thought to be due to axonal disruption, and changes have been well documented in multiple sclerosis lesions. DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisection echoplanar imaging.METHODS:The optic nerves of eighteen patients who had experienced an attack of optic neuritis 1 year previously and 11 control subjects were imaged with the diffusion sequence (usable data were available from 16 patients and 10 control subjects). The orbital optic nerves were segmented by a blinded observer by using a computer-assisted threshold-based contouring technique, and the mean ADC was determined.RESULTS:The mean ADC from diseased optic nerves was 1324 × 10−6mm2/s, compared with 990 × 10−6mm2/s from healthy contralateral optic nerves (P= .005 versus diseased optic nerves) and 928 × 10−6mm2/s from control optic nerves (P= .006 versus diseased optic nerves andP= .40 versus healthy contralateral optic nerves). The diseased optic nerve ADC correlated with both visual (e.g.,rS= 0.73;P= .001 for logMAR visual acuity) and electrophysiological parameters (e.g.,rS= −0.57,P= .021 for visual evoked potential central field amplitude [VEP]).CONCLUSION:It has been possible to apply DW imaging in a patient population, and, in the chronic phase following optic neuritis, the correlation of mean ADC with the clinical and electrophysiological parameters suggests that the ADC is giving a surrogate measure of axonal disruption in the chronic, postinflammatory optic nerve lesion.