A RANDOMIZED, DOUBLE-MASKED STUDY ON THE TREATMENT OF RETINAL VEIN OCCLUSION WITH TROXERUTIN
A RANDOMIZED, DOUBLE-MASKED STUDY ON THE TREATMENT OF RETINAL VEIN OCCLUSION WITH TROXERUTIN
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DOI：
10.1016/s0002-9394(14)75791-5
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发表时间：
1994-10-01
影响因子：
4.2
通讯作者：
SAMAMA, MM
中科院分区：
文献类型：
--
作者：
GLACETBERNARD, A;COSCAS, G;SAMAMA, MM
血液流变学因素可能在视网膜静脉闭塞的发病和预后中起重要作用。因此，我们设计了一项前瞻性、随机、双盲研究来评估曲克鲁丁（一种神学药物）对视网膜静脉闭塞的影响。纳入53例患者，其中视网膜中央静脉阻塞27例，视网膜分支静脉阻塞26例。他们被随机分配使用曲克鲁汀或安慰剂进行治疗。所有受试者在年龄、性别、相关疾病、血液流变学值和视网膜静脉阻塞的临床严重程度方面相似。随访结束时，与安慰剂组相比，曲希鲁汀治疗组在视力（P = 0.03）、黄斑阈值（P = 0.01）、视网膜循环时间（P = 0.04）和黄斑水肿（P = 0.05）方面均有显著改善。此外，与对照组相比，他们的缺血进展减少（P = 0.05），红细胞聚集性降低（P = 0.006）。通过神学治疗获得的这些令人鼓舞的初步结果证明了血液粘度在视网膜静脉闭塞中的致病作用，并建议进行大规模随机研究。
Hemorheologic factors probably play a role in the pathogenesis and prognosis of retinal vein occlusion. Accordingly, we designed a prospective, randomized, double-masked study to evaluate the effect of troxerutin, a theologic drug, on retinal vein occlusion. Fifty-three patients were included, 27 with central retinal vein occlusion and 26 with branch retinal vein occlusion. They were randomly assigned for treatment with either troxerutin or a placebo. All subjects were similar in age, gender, associated diseases, hemorheologic values, and clinical severity of the retinal vein occlusion. At the end of follow-up, members of the troxerutin-treated group, as compared with the placebo group, showed significant improvement in visual acuity (P = .03), macular threshold (P = .01), retinal circulation times (P = .04), and macular edema (P = .05). Furthermore, they had diminished progression of ischemia (P = .05) and decreased red blood cell aggregability (P = .006) when compared with the controls. These encouraging preliminary results obtained with a theologic treatment attest to the pathogenic role of blood viscosity in retinal vein occlusion and suggest that a large-scale randomized study should be conducted.