Intrauterine Exposure to Alcohol and Tobacco Use and Childhood IQ: Findings from a Parental-Offspring Comparison within the Avon Longitudinal Study of Parents and Children
Intrauterine Exposure to Alcohol and Tobacco Use and Childhood IQ: Findings from a Parental-Offspring Comparison within the Avon Longitudinal Study of Parents and Children
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DOI：
10.1203/pdr.0b013e318187cc31
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发表时间：
2008-12-01
影响因子：
3.6
通讯作者：
Lawlor, Debbie A.
中科院分区：
文献类型：
--
作者：
Alati, Rosa;Macleod, John;Lawlor, Debbie A.
这项研究旨在通过宫内机制检验这一假设，即孕妇在怀孕期间适度饮酒和吸烟与儿童智商(IQ)得分有关。在雅芳父母和孩子纵向研究中，我们对吸烟和饮酒与儿童智商之间的关系进行了亲子比较。对4332名参与者进行了分析，获得了怀孕18周时母亲和父亲使用酒精和烟草的完整数据、儿童智商和一系列混杂因素。在儿童8岁时用韦施勒儿童智力量表(WISC-III)测量智商。我们使用多变量线性回归和Logistic回归来估计不同暴露类别的智商得分的平均差异和95%的可信区间，并计算f统计来比较母方和父方的关联。在完全调整的模型中，没有强有力的统计证据表明，母亲怀孕期间的烟酒消费与童年智商之间的关联比父亲的烟酒消费(在其配偶怀孕期间也进行了评估)更大。我们的发现表明，母亲在怀孕早期适度饮酒和吸烟与儿童智商之间的关系可能不能用宫内机制来解释。(儿科：659-666,2008)
This study aims to test the hypothesis that moderate maternal alcohol and tobacco use in pregnancy is associated with intelligent quotient (IQ) scores in childhood through intrauterine mechanisms. We conducted parental-offspring comparisons between the associations of tobacco and alcohol consumption with child's IQ in the Avon Longitudinal Study of Parents and Children. Analyses were conducted on 4332 participants with complete data on maternal and paternal use of alcohol and tobacco at 18 wk gestation, child's IQ and a range of confounders. IQ was measured at child age 8 with the Weschler Intelligence Scale for Children (WISC-III). We used multivariable linear and logistic regression to estimate mean differences and 95% confidence intervals in IQ scores across the exposure categories and computed f statistics to compare maternal and paternal associations. In fully adjusted models, there was no strong statistical evidence that maternal alcohol and tobacco consumption during pregnancy were associated with childhood IQ with any greater magnitude than paternal alcohol and tobacco consumption (also assessed during their partners' pregnancy). Our findings suggest that the relationship between maternal moderate alcohol and tobacco use in early pregnancy and childhood IQ may not be explained by intrauterine mechanisms. (Pediatr Res 64: 659-666, 2008)