Surfactant addition to modify the structures of ethylcellulose oleogels for higher solubility and stability of curcumin
Surfactant addition to modify the structures of ethylcellulose oleogels for higher solubility and stability of curcumin
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DOI：
10.1016/j.ijbiomac.2020.10.115
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发表时间：
2020-12-15
影响因子：
8.2
通讯作者：
Mao, Like
中科院分区：
文献类型：
--
作者：
Liu, Nan;Lu, Yao;Mao, Like
本研究以乙基纤维素(EC)为基础，通过添加表面活性成分(山梨醇单棕榈酸酯，SP)来提高姜黄素的活性负载量，以减少脂质氧化，改善姜黄素的溶解性和化学稳定性。随着SP含量的增加，EC油凝胶具有更紧密的凝胶网络和更均匀的小孔分布。流变学分析表明，凝胶具有剪切稀化行为，SP浓度越高，体系粘度越高。通过频率扫描、蠕变恢复和质构分析确定，SP的加入还有助于增强凝胶强度。含SP量较高的EC油凝胶在离心过程中能保持较多的液体油，核磁共振测定的T-2弛豫时间较短。在含有SP的体系中，油凝胶的过氧化值显著降低，当SP含量为4%或6%时，可有效地抑制贮藏过程中的脂质氧化。当姜黄素被掺入凝胶网络时，由于在9天的储藏试验中DSC没有检测到姜黄素晶体，因此加入SP后其有效浓度保持得更好，并且在紫外光照射8小时时姜黄素的保留率更高。(C)2020爱思唯尔公司版权所有。
The current study developed ethylcellulose (EC) based oleogels with the addition of a surface active ingredient (sorbitanmonopalmitate, SP), in order to increase the active loading of curcumin by reducing lipid oxidation, improving curcumin solubility and chemical stability. With the increase in SP content, EC oleogels had more compact gel networks with evenly distributed smaller pores. Rheological analysis revealed that the gels had shear thinning behavior, and higher concentration of SP contributed to the systems with higher viscosity. The inclusion of SP also worked to reinforce gel strength as determined by frequency sweep, creep recovery and textural analyses. EC oleogels with higher content of SPwere capable to holdmore liquid oil during centrifugation, and the T-2 relaxation timewasmuch lower as determined by NMR. Peroxide value of the oleogelswas significantly lower in the systems with SP, and a SP content of 4% or 6% was effective in inhibiting lipid oxidation during storage. When curcumin was incorporated within the gel networks, its effective concentration was more retained with the addition of SP, as no curcumin crystals were detected by DSC during a 9-day storage test, and curcumin had much higher retention when exposed to UV light for 8 h. (C) 2020 Elsevier B.V. All rights reserved.