Long-term study of large ceramic implants (porous hydroxyapatite) in dog femora.
Long-term study of large ceramic implants (porous hydroxyapatite) in dog femora.
复制标题
狗股骨大型陶瓷植入物（多孔羟基磷灰石）的长期研究。
DOI：
10.1097/00003086-198407000-00043
复制
发表时间：
1984
影响因子：
4.2
通讯作者：
P. Wittebol
中科院分区：
文献类型：
--
作者：
H. Hoogendoorn;W. Renooij;L. Akkermans;W. Visser;P. Wittebol
将多孔陶瓷羟基磷灰石块(尺寸2.5×1.25×0.5 cm；烧结温度1300度；大孔率56%；平均孔径0.18mm2)植入犬股骨手术造成的缺损区。植入物在植入后长达3.5年被收回。种植体植入时间为3.5年。植入物牢固地附着在骨头上。组织学评估表明，应提供最佳的骨与种植体之间的接触，以加速骨向内生长。在35周后，毛孔中的骨生长达到最大水平，此时大约三分之一的毛孔空间被骨填充。在组织学切片上测量骨和陶瓷的相对表面积时，没有检测到陶瓷质量的变化，表明羟基磷灰石陶瓷不受生物降解过程的影响。植入物有效地为骨生长提供了支架，弥补了较大的骨缺损。
Blocks of porous ceramic hydroxyapatite (dimensions, 2.5 X 1.25 X 0.5 cm; sintering temperature, 1300 degrees; macroporosity, 56%; average pore size 0.18 mm2) were implanted into surgically created defects in dog femora. The implants were retrieved up to 3.5 years after implantation. The implants were 3.5 years after implantation. The implants were firmly attached to the bone. Histologic evaluation suggests that optimal contact between bone and implant should be provided to accelerate bone ingrowth. Bone growth in the pores reached a maximum level after 35 weeks, at which time about one-third of the pore space was filled with bone. When measuring the relative surface areas of bone and ceramic on histologic slides, no change in ceramic mass could be detected, indicating that hydroxyapatite ceramics are not affected by biodegradation processes. The implants effectively provided a scaffold for bone growth bridging a larger bone defect.