Mice and the A-Bomb: Irradiation Systems for Realistic Exposure Scenarios
Mice and the A-Bomb: Irradiation Systems for Realistic Exposure Scenarios
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DOI：
10.1667/rr008cc.1
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发表时间：
2017-04-01
影响因子：
3.4
通讯作者：
Brenner, David J.
中科院分区：
文献类型：
--
作者：
Garty, Guy;Xu, Yanping;Brenner, David J.
生物剂量测定的验证通常通过急性暴露于均匀的外部光子场来进行。实际上，暴露于放射性扩散装置或反应堆泄漏将包括暴露于低剂量率以及可能暴露于摄入的放射性核素。除了高剂量率和低剂量率光子以及摄入的放射性核素的混合物之外，简易核装置可能还包括重要的中子成分。我们在此介绍高通量微创辐射生物剂量测定中心开发的几种新型辐照系统，为新型生物剂量测定的测试提供更真实的暴露。这些辐照器提供各种剂量率（从戈瑞/秒到戈瑞/周）以及模仿简易核装置的混合中子/光子场。 (C) 2017 年放射线研究会
Validation of biodosimetry assays is normally performed with acute exposures to uniform external photon fields. Realistically, exposure to a radiological dispersal device or reactor leak will include exposure to low dose rates and likely exposure to ingested radionuclides. An improvised nuclear device will likely include a significant neutron component in addition to a mixture of high-and low-dose-rate photons and ingested radionuclides. We present here several novel irradiation systems developed at the Center for High Throughput Minimally Invasive Radiation Biodosimetry to provide more realistic exposures for testing of novel biodosimetric assays. These irradiators provide a wide range of dose rates (from Gy/s to Gy/week) as well as mixed neutron/photon fields mimicking an improvised nuclear device. (C) 2017 by Radiation Research Society