From Pyrone to Thiopyrone Ligands-Rendering Maltol-Derived Ruthenium(II)-Arene Complexes That Are Anticancer Active in Vitro
From Pyrone to Thiopyrone Ligands-Rendering Maltol-Derived Ruthenium(II)-Arene Complexes That Are Anticancer Active in Vitro
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DOI：
10.1021/om900483t
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发表时间：
2009-08-10
期刊：
影响因子：
2.8
通讯作者：
Keppler, Bernhard K.
中科院分区：
文献类型：
--
作者：
Kandioller, Wolfgang;Hartinger, Christian G.;Keppler, Bernhard K.
通过用S，O供体取代配位的O，O供体，使具有吡喃酮衍生配体的Ru（II）-芳烃络合物对癌细胞具有活性。这些系统的不同的稳定性可以解释观察到的影响的供体原子在体外的抗癌活性。
Ru(II)-arene complexes with pyrone-derived ligands are rendered active against cancer cells by replacement of the coordinated O,O donor with an S,O donor. The different stabilities of these systems may explain the observed influence of the donor atoms on the anticancer activity in vitro.