The mycobiome in HIV.
The mycobiome in HIV.
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DOI：
10.1097/coh.0000000000000432
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发表时间：
2018-01
影响因子：
4.1
通讯作者：
Ghannoum MA
中科院分区：
文献类型：
--
作者：
Hager CL;Ghannoum MA
调查微生物组与艾滋病毒之间关联的研究数量有限。尽管大多数已发表的研究都集中在细菌群落（细菌组）在这种情况下的作用，但少数研究也描述了艾滋病毒感染者中真菌组的作用。本综述将总结有关真菌群落在艾滋病毒中的作用的最新报告。据报道，艾滋病毒感染者与未感染者的口腔和呼吸道真菌群组成存在差异。我们的综述表明，严重缺乏调查真菌组在艾滋病毒环境中作用的研究。随着我们对人类微生物群组成的了解的最新进展，对构成整个微生物群的细菌和真菌的作用以及两者如何相互作用以相互影响和宿主的研究至关重要。
There are a limited number of studies investigating the association between the microbiome and HIV. Although the majority of these published investigations have focused on the role of the bacterial community (bacteriome) in this setting, a handful of studies have also characterized the role of the mycobiome in HIV-infected individuals. This review will summarize the most recent reports pertaining to the role of the fungal community in HIV. Differences in the composition of the oral and respiratory mycobiome in HIV-infected individuals compared to uninfected individuals have been reported. Our review shows that studies investigating the role of the mycobiome in the setting of HIV are severely lacking. With recent advances in our understanding of the composition of the human microbiome, investigations into the role of the bacteria and fungus comprising the overall microbiota and how the two interact to influence each other and the host is crucial.