Species-specific and interspecies relatedness of NSP1 sequences in human, porcine, bovine, feline, and equine rotavirus strains
Species-specific and interspecies relatedness of NSP1 sequences in human, porcine, bovine, feline, and equine rotavirus strains
复制标题
人、猪、牛、猫和马轮状病毒株中 NSP1 序列的物种特异性和种间相关性
作者：
K. Kojima;K. Taniguchi;N. Kobayashi
我们对3个人、2个猪、2个牛、1个猫和5个马轮状病毒株的NSP 1基因5进行了测序，并将核苷酸和推导的氨基酸序列与已发表的其他各种毒株的序列进行了比较。发现亚组I人类菌株L26、69 M和DS-1具有相似的NSP 1序列，尽管它们的G血清型、VP 4基因型和RNA模式不同。人株K8的NSP 1序列与猪株OSU和YM的NSP 1序列具有高度的同源性。高度的同源性被发现之间的三个马菌株（H2，FI-14，和FI 23），但他们不同于其他马菌株L338和H1。菌株H1与猪的菌株相似。猫菌株Cat 2与牛菌株UK、RF和A44具有高度同源性。结果表明，人、猪、牛、猫和马轮状病毒NSP 1基因序列具有种间和种特异性，L26和YM株与不同的人和动物轮状病毒株的基因组序列具有种间和种间的相关性。目前和以前的杂交结果表明，在大多数菌株的整体基因组特性（或基因组）和NSP 1序列同源性之间有很好的相关性。
SummaryWe have sequenced gene 5 encoding NSP1 for three human, two porcine, two bovine, one feline, and five equine rotavirus strains, and compared the nucleotide and deduced amino acid sequences with the published sequences for other various strains. Subgroup I human strains L26, 69M, and DS-1 were found to have a similar NSP1 sequence despite their different G serotypes, VP4 genotypes, and RNA patterns. The NSP1 sequence of the human strain K8 showed a high degree of homology to those of porcine strains OSU and YM. A high degree of homology was found among three equine strains (H2, FI-14, and FI23), but they differed from the other equine strains L338 and H1. The strain H1 was similar to the porcine strains. The feline strain Cat2 showed a high homology to bovine strains UK, RF, and A44. Thus, species-specific and interspecies relatedness of NSP1 sequences among human, porcine, bovine, feline and equine rotaviruses was found. Overall genomic relatedness of strains L26 and YM to various human and animal strains was also examined by RNA-RNA hybridization assay. The present and previous hybridization results showed that there is a good correlation in most strains between overall genomic property (or genogroup) and NSP1 sequence homology.
轮状病毒非结构 RNA 结合蛋白 NS35 的核苷酸和氨基酸序列分析。
影响因子：
3.7
作者：
Patton,JT;Salter-Cid,L;Kalbach,A;Mansell,EA;Kattoura,M
通讯作者：
Kattoura,M