Plasma Adiponectin Concentrations Are Associated with Body Composition and Plant-Based Dietary Factors in Female Twins
Plasma Adiponectin Concentrations Are Associated with Body Composition and Plant-Based Dietary Factors in Female Twins
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DOI：
10.3945/jn.108.098681
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发表时间：
2009-02-01
影响因子：
4.2
通讯作者：
MacGregor, Alex J.
中科院分区：
文献类型：
--
作者：
Cassidy, Aedin;Skidmore, Paula;MacGregor, Alex J.
循环脂联素正在成为肥胖、2型糖尿病和心血管疾病（CVD）之间的重要联系。然而，调节脂联素浓度的生活方式因素谱仍有待阐明，特别是在女性中。我们对来自TwinsUK成人双胞胎登记处的877对女性双胞胎进行了横断面研究。采用双胎设计，我们通过配对内分析来检查饮食和身体成分对脂联素的影响，以消除混淆。在对双胞胎进行多变量调整后，非淀粉多糖（3.25%,95%Cl: 0.06, 6.54, P < 0.05）和镁摄入量（3.80%,95%Cl: 0.17, 7.57, P < 0.05）显著影响了脂联素（对数转换，每SD变化百分比），水果和蔬菜（F&V）摄入量（2.55%,95%Cl: -0.26, 5.45, P = 0.08）也有相关性。这些适度的积极联系不能通过双胞胎共有的其他生活方式因素来解释。脂联素与3种衍生饮食模式（F&V、节食、传统英语）、碳水化合物、蛋白质、反式脂肪和酒精摄入之间也存在显著关系。BMI （-10.72%, 95% Cl: - 13.78, -7.55）、total （-6.89%, 95% Cl: -10.34, -3.30, P < 0.05）、central fat mass （-12.50%, 95% Cl: 15.82, -9.05, P < 0.05）与脂联素呈显著负相关；当双胞胎作为个体进行分析时，这些关系都很重要，当双胞胎之间的特征对比时，这表明了直接的影响。我们在女性双胞胎中观察到饮食因素和脂联素之间的适度关联，独立于肥胖，并报告了与身体成分的强烈负相关。这些数据强调了维持体重和增加富含植物性食物的饮食对于预防心血管疾病和2型糖尿病的重要性。J.Nutr。139:353 - 358, 2009。
Circulating adiponectin is emerging as an important link between obesity, type 2 diabetes, and cardiovascular disease (CVD). However, the spectrum of lifestyle factors that modulate the adiponectin concentration remains to be elucidated, particularly among women. We conducted a cross-sectional study of 877 female twin pairs from the TwinsUK adult twin registry. Using a co-twin design, we examined dietary and body composition influences on adiponectin by conducting matched, within pair analyses to eliminate confounding. Following multivariable adjustment within-twin pairs, significant influences on adiponectin (log-transformed, percent change per SD of the dietary/body composition variable) were observed for nonstarch polysaccharides (3.25%; 95% Cl: 0.06, 6.54; P < 0.05) and magnesium intake (3.80%; 95%Cl: 0.17, 7.57; P < 0.05), with a trend toward an association for fruit and vegetable (F&V) intakes (2.55%; 95% Cl: -0.26, 5.45; P = 0.08). These modest positive associations cannot be explained by confounding through other lifestyle factors shared by the twins. A significant relationship between adiponectin and 3 derived dietary patterns (F&V, dieting, traditional English), carbohydrate, protein, trans fat, and alcohol intake was also observed. Strong inverse associations with adiponectin were observed for BMI (-10.72%; 95% Cl: - 13.78, -7.55), total (-6.89%: 95% Cl: -10.34, -3.30; P < 0.05), and central fat mass (-12.50%; 95% Cl: 15.82, -9.05; P < 0.05); these relationships were significant both when twins were analyzed as individuals and when characteristics were contrasted within-twin pairs, suggesting a direct effect. We observed modest associations between dietary factors and adiponectin in female twins, independent of adiposity, and report strong inverse associations with body composition. These data reinforce the importance of weight maintenance and increasing consumption of diets rich in plant-based foods to prevent CVD and type 2 diabetes. J.Nutr. 139:353-358, 2009.