Nationwide epidemiologic survey of Kawasaki disease in Japan, 2015-2016
Nationwide epidemiologic survey of Kawasaki disease in Japan, 2015-2016
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DOI：
10.1111/ped.13809
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发表时间：
2019-04-01
影响因子：
1.4
通讯作者：
Yanagawa, Hiroshi
中科院分区：
文献类型：
--
作者：
Makino, Nobuko;Nakamura, Yosikazu;Yanagawa, Hiroshi
背景自川崎病(Kawasaki disease，KD)首次报道以来，距今已近50年。KD全国范围的调查始于1970年。尽管日本已经报告了360000个病例，但原因仍不清楚。在日本，KD的患者数量和发病率持续上升。方法2017年进行了全国2015年和2016年的病例发病率调查，为全国第24次KD调查。对拥有100张床位的医院和儿科专科医院的儿科科室进行问卷调查，儿科主治医师进行问卷调查。结果2年共收治患者31595例，男女性别比为1.3 4。2015年发病率(100000-4岁/年儿童)为330.2(男孩371.2，女孩287.3)，2016年为309.0(男孩343.2，女孩273.2)。按月计算的患者数量在1月份达到顶峰。年龄别发病率以9~11个月龄儿童最高，以后随年龄增长发病率逐渐下降。结论总结了最新的全国KD调查情况，考虑了流行病学图景的变化。
BackgroundApproximately 50years have passed since Kawasaki disease (KD) was first reported. The KD nationwide survey began in 1970. Although >360000 cases have already been reported in Japan, the cause is still unknown. In Japan, the number of patients and incidence rate of KD has continued to increase. It is necessary to examine the trend of the occurrence in the surveillance of KD.MethodsThe nationwide survey of patient incidence in 2015 and 2016 was conducted in 2017, as the 24th nationwide survey of KD. A questionnaire was sent to pediatric departments in hospitals with >100 beds and specialized pediatric hospitals, and was responded to by the attending pediatricians.ResultsThe total number of patients in 2years was 31595, and the sex ratio (male/female) was 1.34. The incidence rate (/100000 children aged 0-4years/year) was 330.2 (371.2 in boys, 287.3 in girls) in 2015, and 309.0 (343.2 in boys, 273.2 in girls) in 2016. The number of patients by month peaked in January. The age-specific incidence rate according to sex was highest in children between 9 and 11months of age, after which the incidence rate gradually decreased with advancing age.ConclusionsWe summarize the most recent nationwide survey of KD and consider the change in the epidemiologic picture.