Cancer patient survival--patterns, comparisons, trends--a population-based Cancer Registry study in Finland.
Cancer patient survival--patterns, comparisons, trends--a population-based Cancer Registry study in Finland.
复制标题
癌症患者生存——模式、比较、趋势——芬兰一项基于人群的癌症登记研究。
DOI：
10.1080/028418699431348
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发表时间：
1999
期刊：
影响因子：
3.1
通讯作者：
B. Söderman
中科院分区：
文献类型：
--
作者：
L. Teppo;P. Dickman;T. Hakulinen;T. Luostarinen;E. Pukkala;R. Sankila;B. Söderman
根据 1985 年至 1994 年芬兰癌症登记处基于人群的材料，分析了原发部位、性别、年龄、分期和组织学类型对癌症患者生存的影响。此外，还构建了 1955 年至 1994 年期间的生存趋势。详细的特定地点数据作为第 12 卷的补充 12 发布。肿瘤学报 38。在给定地点内，不同性别的生存差异并不大。然而，由于部位分布不同，所有部位综合起来，女性患者的平均预后优于男性：5年相对生存率（RSR）分别为58%和43%。一般来说，与年轻患者相比，老年患者的预后较差（部分原因是分期和组织学分布不同）。分期是患者生存的重要决定因素。在一些平均预后较差的癌症中，局部肿瘤的 5 年 RSR 是合理的，例如男性胃癌占 61%，女性胆囊癌占 34%，男性肺癌占 29%。大多数存活率随着时间的推移明显增加。除了癌症治疗的改进之外，其他几个因素随时间的变化也会影响趋势，例如分期分布的变化（由于健康教育、改进的诊断方法、筛查等而导致的早期诊断）以及由于癌症定义的变化而导致的患者材料组成的变化（例如乳头状瘤与膀胱乳头状癌、甲状腺隐匿性癌和早期前列腺癌）。庞大的癌症登记材料（466,000 名患者）能够准确估计芬兰癌症患者的生存率。这些比率反映了整个医疗保健系统的有效性，可用于规划和评估目的。然而，估计的生存率是基于分组数据，不能直接用于预测个体患者的预后，尽管它们可以用作指南。
The effects of primary site, sex, age, stage and histological type on cancer patient survival were analysed on the basis of the population-based material of the Finnish Cancer Registry from 1985 to 1994. In addition, trends in survival were constructed for the period 1955-1994. Detailed site-specific data are published as Supplement 12 to Vol. 38 of Acta Oncologica. Within a given site, the survival differences by gender were not large. However, because of different site distributions, the average prognosis for female patients, all sites taken together, was superior to that of males: the 5-year relative survival rates (RSR) were 58% and 43%, respectively. In general, older patients had a poorer outcome compared with younger patients (partly because of different stage and histology distributions). Stage was a strong determinant of patient survival. In some cancers with a poor average prognosis the 5-year RSR for localized tumours was reasonable, e.g. 61% for stomach cancer, males, 34% for gallbladder cancer, females, and 29% for lung cancer, males. Most of the survival rates clearly increased over time. In addition to improvements in cancer treatment, changes over time in several other factors affect the trends, such as changes in the stage distribution (early diagnosis as a result of health education, improved diagnostic methods, screening, etc.) and in the composition of the patient material because of changing definitions of cancer (e.g. papilloma versus papillary carcinoma of the bladder, occult carcinoma of the thyroid, and early prostate cancer). The large Cancer Registry material (466,000 patients) enabled accurate estimates of the survival rates of cancer patients in Finland. These rates reflect the effectiveness of the healthcare system as a whole and are useful for planning and evaluation purposes. However, the estimated survival rates are based on grouped data, and cannot be directly applied for predicting the prognoses of individual patients, although they can be used as guidelines.