Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8).
Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8).
复制标题
衰老加速小鼠 (SAMP8) 中与年龄相关的昼夜节律和记忆中断。
DOI：
10.1007/s11357-006-9013-9
复制
发表时间：
2006
期刊：
影响因子：
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通讯作者：
McAuley,JDevin
中科院分区：
文献类型：
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作者：
Pang,KevinCH;Miller,JonathanP;Fortress,Ashley;McAuley,JDevin
老年人的常见主诉涉及认知能力受损，例如记忆力丧失和无法照顾。虽然很多研究都致力于这些认知障碍，但其他因素，如睡眠模式中断和白天嗜睡增加，可能间接导致认知能力受损。睡眠-觉醒周期的中断可能是由于年龄相关的内部（昼夜节律）时钟变化的结果。在这篇文章中，我们回顾了最近的研究，衰老和昼夜节律的重点是衰老加速小鼠（SAM）作为一种模型的老化。我们探讨了一些神经生物学机制，似乎是负责我们的老化时钟，并考虑这项工作的影响与年龄相关的认知变化。
Common complaints of the elderly involve impaired cognitive abilities, such as loss of memory and inability to attend. Although much research has been devoted to these cognitive impairments, other factors such as disrupted sleep patterns and increased daytime drowsiness may contribute indirectly to impaired cognitive abilities. Disrupted sleep–wake cycles may be the result of age-related changes to the internal (circadian) clock. In this article, we review recent research on aging and circadian rhythms with a focus on the senescence-accelerated mouse (SAM) as a model of aging. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for age-related changes in cognition.