Sensitivity of exercise-induced increase in hepatic glucose production to glucose supply and demand.
Sensitivity of exercise-induced increase in hepatic glucose production to glucose supply and demand.
复制标题
运动引起的肝葡萄糖产生增加对葡萄糖供应和需求的敏感性。
DOI：
10.1152/ajpendo.1994.267.3.e411
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Wasserman,DH
中科院分区：
文献类型：
--
作者：
Berger,CM;Sharis,PJ;Bracy,DP;Lacy,DB;Wasserman,DH
据推测，运动引起的糖调节激素和葡萄糖产生（Ra）的变化是由于葡萄糖可用性的小赤字。为了测试这一点，禁食18小时的狗进行150分钟的跑步机运动，其中肝脏作为葡萄糖的唯一来源（对照，n = 5）或以设计用于跟踪葡萄糖利用（Rd）反应的速率在0至50分钟（阶段1）和100至150分钟（阶段3）输注葡萄糖（ExoGlc，n = 5）。肝脏单独提供葡萄糖50至100分钟（第2阶段）。使用同位素和动静脉方法评估Ra、Rd和糖异生（GNG）。变量[3 H]葡萄糖输注和频繁采样用于促进Ra测量。在对照组中，动脉葡萄糖在第1-3阶段分别下降了-3.1 +/- 1.4、-4.3 +/- 2.9和-6.4 +/- 3.7 mg/dl（变化是每个50分钟阶段的平均值; P < 0.05）。在ExoGlc中，动脉葡萄糖在第1阶段（+0.1 +/-1.8mg/dl）和第3阶段（+1.5 +/-4.5mg/dl）没有偏离基础，但在第2阶段（-5.7 +/-2.1mg/dl）从基础下降（P < 0.05），下降量与对照相同。RD反应与外源性葡萄糖匹配导致动脉和门静脉血浆胰岛素水平升高（P < 0.05），但不影响胰高血糖素、去甲肾上腺素、肾上腺素和皮质醇水平。在第1-3阶段，对照组的Ra分别升高3.1 +/- 0.5、4.0 +/- 1.1和4.7 +/- 1.1 mg.kg-1.min-1（P < 0.05）。在ExoGlc中，在第1-3阶段，Ra分别升高0.0 +/- 0.4、4.1 +/- 1.4（P < 0.05）和0.4 +/- 0.7 mg.kg-1.min-1。与对照组相比，在ExoGlc的第1和第3阶段，Ra的升高降低（P < 0.02）。GNG在对照中上升至约250%基础，并且在ExoGlc中没有任何显著差异的响应。总之，运动诱导的反调节激素和GNG的增加是存在的，即使在葡萄糖供应的赤字是由外源性葡萄糖输注消除。相反，胰岛素的下降和肝糖原分解的上升大大减弱。受外源性葡萄糖影响的调节组分在肝脏中占主导地位，因为约4%的血浆葡萄糖偏差对应于约60%的Ra变化。（400字处截断摘要）
It was hypothesized that the exercise-induced changes in glucoregulatory hormones and glucose production (Ra) occur as a result of a small deficit in glucose availability. To test this, 18-h fasted dogs performed 150 min of treadmill exercise with either the liver as the sole source of glucose (controls, n = 5) or with glucose infused from 0 to 50 min (period 1) and from 100 to 150 min (period 3) at rates designed to track the glucose utilization (Rd) response (ExoGlc, n = 5). The liver alone supplied glucose from 50 to 100 min (period 2). Isotopic and arteriovenous methods were used to assess Ra, Rd, and gluconeogenesis (GNG). Variable [3H]glucose infusion and frequent sampling were used to facilitate Ra measurements. Arterial glucose declined by -3.1 +/- 1.4, -4.3 +/- 2.9, and -6.4 +/- 3.7 mg/dl in periods 1-3 in controls (changes are mean values during each of the 50-min periods; P < 0.05). In ExoGlc, arterial glucose did not deviate from basal in periods 1 (+0.1 +/- 1.8 mg/dl) and 3 (+1.5 +/- 4.5 mg/dl) but fell from basal (P < 0.05) by the same amount as controls in period 2 (-5.7 +/- 2.1 mg/dl). Matching the Rd response with exogenous glucose led to increases in arterial and portal vein plasma insulin levels (P < 0.05) but did not affect glucagon, norepinephrine, epinephrine, and cortisol levels. Ra was elevated by 3.1 +/- 0.5, 4.0 +/- 1.1, and 4.7 +/- 1.1 mg.kg-1.min-1 in periods 1-3 in controls (P < 0.05). In ExoGlc, Ra rose by 0.0 +/- 0.4, 4.1 +/- 1.4 (P < 0.05), and 0.4 +/- 0.7 mg.kg-1.min-1, respectively, in periods 1-3. The rise in Ra was reduced in periods 1 and 3 of ExoGlc compared with controls (P < 0.02). GNG rose to approximately 250% basal in controls and did not respond with any significant difference in ExoGlc. In summary, the exercise-induced increases in counterregulatory hormones and GNG are present even when a deficit in glucose supply is eliminated by an exogenous glucose infusion. In contrast, the fall in insulin and the rise in hepatic glycogenolysis are greatly attenuated. The regulatory components affected by exogenous glucose predominate at the liver as deviations in plasma glucose of approximately 4% correspond to approximately 60% changes in Ra.(ABSTRACT TRUNCATED AT 400 WORDS)
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影响因子：
64.8
作者：
C. Humphries;A. Shen;W. Kuziel;J. Capra;F. Blattner;P. Tucker
通讯作者：
P. Tucker