UV-induced skin cancer: similarities--variations.
UV-induced skin cancer: similarities--variations.
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DOI：
10.1111/j.1610-0387.2005.05037.x
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发表时间：
2005-07-01
期刊：
影响因子：
--
通讯作者：
Boukamp, Petra
中科院分区：
文献类型：
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作者：
Boukamp, Petra
皮肤癌是世界上最常见的癌症，包括不同的肿瘤实体：角质形成细胞源性基底细胞癌（BCC）和鳞状细胞癌（SCC）以及神经外胚层恶性黑色素瘤（MM）和神经内分泌默克尔细胞癌（MCC）。虽然关于导致 BCC 和 MM 的遗传变化的知识显着增加，但我们对 SCC 和 MCC 的发展和进展的了解仍然不完整。因此，本综述的目的是，一方面总结现有知识，但不要求完整性，另一方面提供 HaCaT 体外皮肤癌发生模型的信息，该模型用于评估被认为在皮肤癌发生和进展中发挥作用的遗传畸变的功能后果。
Skin cancer, the most common cancer world wide, encompasses different tumor entities, the keratinocyte-derived basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) as well as the neuroectodermal malignant melanoma (MM) and the neuroendocrine Merkel cell carcinomas (MCC). While knowledge is significantly increasing about genetic changes contributing to BCCs and MMs, our understanding for the development and progression of SCCs and MCCs is still fragmentary. This review, thus, aims, on the one hand to summarize the present knowledge without claiming completeness and, on the other hand, to provide information on the HaCaT in vitro skin carcinogenesis model that is used to evaluate the functional consequence of genetic aberrations believed to play a role in skin cancer development and progression.