Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome
Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome
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DOI：
10.1016/s0002-9343(01)00948-2
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发表时间：
2001-12-01
影响因子：
5.9
通讯作者：
Dunaif, A
中科院分区：
文献类型：
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作者：
Legro, RS;Kunselman, AR;Dunaif, A
目的：患有多囊卵巢综合征的女性患有高雄激素血症和胰岛素抵抗，这与循环脂质和脂蛋白水平的改变有关。我们试图确定这些女性中血脂异常的患病率和危险因素。 对象和方法：患有多囊卵巢综合征的非西班牙裔白人女性 (n = 195) 和种族匹配的对照女性 (n = 62) 采集了空腹血以检测激素和血脂水平。根据体重指数对受试者进行分类（非肥胖 < 27 kg/m(2)，肥胖 ≥27 kg/m(2)），并根据年龄调整分析。 结果：与肥胖对照女性（n = 35；总胆固醇水平平均差值 = 29 mg/dL）相比，患有多囊卵巢综合征的肥胖女性 (n = 153) 的总胆固醇和低密度脂蛋白胆固醇 (LDL-C) 水平显着升高； 95% 置信区间 [CI]：14 至 45 mg/dL；
PURPOSE: Women with polycystic ovary syndrome are hyperandrogenemic and insulin resistant, which are associated with alterations in circulating lipid and lipoprotein levels. We sought to determine the prevalence of, and risk factors for, lipid abnormalities in these women.SUBJECTS AND METHODS: Non-Hispanic white women with polycystic ovary syndrome (n = 195) and ethnically matched control women (n = 62) had fasting blood obtained for hormone and lipid levels. Subjects were categorized by body mass index (nonobese < 27 kg/m(2), obese ≥27 kg/m(2)), and analyses were adjusted for age.RESULTS: Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels increased significantly in obese women with polycystic ovary syndrome (n = 153) compared with obese control women (n = 35; mean difference in total cholesterol level = 29 mg/dL; 95% confidence interval [CI]: 14 to 45 mg/dL; P