Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus
Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus
复制标题
DOI：
10.1056/nejmoa035471
复制
发表时间：
2003-12-18
影响因子：
158.5
通讯作者：
Salmon, JE
中科院分区：
文献类型：
--
作者：
Roman, MJ;Shanker, B;Salmon, JE
背景：虽然系统性红斑狼疮与早发性心肌梗死有关，但在一项病例对照研究中尚未研究其潜在动脉粥样硬化的患病率及其与心血管疾病的传统危险因素和狼疮相关因素的关系。方法：我们对197例狼疮患者和197名匹配的对照组进行了颈动脉超声、超声心动图和心血管疾病危险因素的评估。对患者的临床和血清学特征、炎症介质和疾病治疗进行评估。结果：患者和对照组心血管疾病的危险因素相似。动脉粥样硬化(颈动脉斑块)发生率(37.1%)明显高于对照组(15.2%，P
BACKGROUND: Although systemic lupus erythematosus is associated with premature myocardial infarction, the prevalence of underlying atherosclerosis and its relation to traditional risk factors for cardiovascular disease and lupus-related factors have not been examined in a case-control study.METHODS: In 197 patients with lupus and 197 matched controls, we performed carotid ultrasonography, echocardiography, and an assessment for risk factors for cardiovascular disease. The patients were also evaluated with respect to their clinical and serologic features, inflammatory mediators, and disease treatment.RESULTS: The risk factors for cardiovascular disease were similar among patients and controls. Atherosclerosis (carotid plaque) was more prevalent among patients than the controls (37.1 percent vs. 15.2 percent, P