TEMPORAL VARIATION IN HUMORAL AND CELL-MEDIATED IMMUNE-RESPONSE IN A SIGMODON HISPIDUS POPULATION
TEMPORAL VARIATION IN HUMORAL AND CELL-MEDIATED IMMUNE-RESPONSE IN A SIGMODON HISPIDUS POPULATION
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DOI：
10.2307/1939397
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发表时间：
1994-01-01
期刊：
影响因子：
4.8
通讯作者：
MCMURRY, ST
中科院分区：
文献类型：
--
作者：
LOCHMILLER, RL;VESTEY, MR;MCMURRY, ST
我们研究了这样的假设：环境引起的免疫能力改变是调节种群生存的主要生理机制。疾病和免疫能力在小型哺乳动物种群调节中的作用尚不清楚，但生理应激和免疫之间的密切关系已被证明。它的参与得到了几项研究的进一步支持，这些研究提供了生存率、疾病发生率和选定的总体免疫指标随密度和季节而暂时变化的证据。我们通过记录一群棉鼠（Sigmodon hispidus）的体液和细胞介导的免疫功能的选定测量值是否存在时间变化来检验这一假设，棉鼠是一种已知密度波动很大的物种，居住在俄克拉荷马州中部的高草草原。 1989年8月至1991年5月，采用常规活捉法，共采集棉鼠310只（10个）。除了初级和次级淋巴器官的形态特征外，还测量了脾细胞响应单次注射绵羊红细胞而产生特异性抗体的能力以及响应体外暴露于有丝分裂原而增殖的能力，以评估免疫能力。收集全血用于测定外周血白细胞总数、细胞堆积体积和血清总蛋白。除血清总蛋白外，这 10 个集合中的所有变量均存在统计学上的显着差异，并且大多数这种变异性与特定的季节时间段无关。双峰节律是几种免疫能力测量的时间变化的特征。该人群平均免疫能力随时间的变化可能反映了基因型多态性的变化；还提供了其他几种合理的解释来解释观察到的时间模式。
We examined the hypothesis that environmentally induced alteration of immunocompetence is a primary physiological mechanism by which population survival is regulated. The involvement of disease and immunocompetence in the regulation of small mammal populations is not well understood but a strong relationship between physiological stress and immunity has been demonstrated. Its involvement is further supported by several studies, which have provided evidence that survival, incidence of disease, and selected gross measures of immunity change temporally with density and season. We examined this hypothesis by documenting the existence of temporal alterations in selected measures of both humoral and cell-mediated immune function in a population of cotton rats (Sigmodon hispidus), a species known to fluctuate widely in density, inhabiting a tallgrass prairie in central Oklahoma. A total of 310 cotton rats was collected from August 1989 to May 1991 (10 collections) using conventional live-trap methods. In addition to morphological characteristics of primary and secondary lymphoid organs, the ability of splenocytes to produce specific antibody in response to a single injection of sheep erythrocytes and to proliferate in response to in vitro exposure to mitogens was measured to assess immunocompetence. Whole blood was collected for the determination of total peripheral blood leukocyte counts, packed cell volume, and total serum proteins. Statistically significant differences in all variables except total serum protein existed among the 10 collections and most of this variability was independent of specific seasonal time periods. Bimodal rhythmicity was characteristic of temporal changes for several measures of immunocompetence. Changes over time in the average immunocompetence of this population could have reflected a shift in genotypic polymorphism; several other plausible explanations are offered to explain the observed temporal patterns.