Molecular and cellular regulation of pancreatic acinar cell function.
Molecular and cellular regulation of pancreatic acinar cell function.
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DOI：
10.1097/mog.0b013e32832ebfac
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发表时间：
2009-09
影响因子：
2.5
通讯作者：
Thrower E
中科院分区：
文献类型：
--
作者：
Husain S;Thrower E
这篇综述主要集中在过去一年的研究，这些研究极大地促进了我们对胰腺腺泡细胞功能的分子和细胞调控的理解。最近的进展集中在控制胰腺发育、腺泡细胞命运、胰腺生长和分泌的信号。胰腺炎后腺泡细胞的再生依赖于成熟腺泡细胞中胚胎信号的表达。在这种情况下，腺泡细胞也可以转分化为脂肪细胞。在某些早期和内分泌驱动的转录因子的强制诱导下，腺泡细胞也可以转分化为β-细胞。对腺泡到导管的化生以及随后胰腺上皮内瘤变病变的形成也有了更多的了解。多种参与分泌的蛋白质已被鉴定，包括小三磷酸鸟苷结合蛋白、可溶性N-乙基马来酰亚胺敏感因子结合蛋白和离子通道。这些发现证明了腺泡细胞的再生潜力，以减轻损伤状态，如胰腺炎。腺泡细胞转分化为β细胞的能力可能为治疗糖尿病提供潜在的途径。最后，研究结果可能有助于预防腺泡细胞的恶性转化事件。蛋白质组学和计算机模拟的发展可以扩展我们对蛋白质介导腺泡细胞功能的看法。
This review focuses on studies from the past year that have greatly advanced our understanding of molecular and cellular regulation of pancreatic acinar cell function. Recent advances focus on signals dictating pancreatic development, acinar cell fate, pancreatic growth, and secretion. Regeneration of acinar cells after pancreatitis depends on expression of embryonic signals in mature acinar cells. In this setting, acinar cells can also transdifferentiate into adipose cells. With the forced induction of certain early and endocrine-driving transcription factors, acinar cells can also transdifferentiate into β-cells. There has also been an increased understanding of acinar-to-ductal metaplasia and the subsequent formation of pancreatic intraepithelial neoplasia lesions. Multiple proteins involved in secretion have been characterized, including small guanosine triphosphate-binding proteins, soluble N-ethylmaleimide-sensitive factor attachment proteins, and ion channels. These findings demonstrate the regenerative potential of the acinar cell to mitigate injurious states such as pancreatitis. The ability of acinar cells to transdifferentiate into β-cells could potentially provide a treatment for diabetes. Finally, the results might be helpful in preventing malignant transformation events arising from the acinar cell. Developments in proteomics and computer modeling could expand our view of proteins mediating acinar cell function.