A randomized controlled trial of the efficacy of autologous platelet therapy for the treatment of osteoarthritis in dogs
A randomized controlled trial of the efficacy of autologous platelet therapy for the treatment of osteoarthritis in dogs
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DOI：
10.2460/javma.243.9.1291
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发表时间：
2013-11-01
影响因子：
1.9
通讯作者：
Bertone, Alicia L.
中科院分区：
文献类型：
--
作者：
Fahie, Maria A.;Ortolano, Girolamo A.;Bertone, Alicia L.
目的：观察单次关节内注射自体浓缩血小板治疗犬骨关节炎的疗效。设计：随机、对照、双中心临床试验。动物实验：20只患有单关节骨关节炎的宠物狗。操作步骤-狗被随机分配到治疗组或对照组。所有狗的跛行和疼痛的严重程度分别由主人用哈德逊视觉模拟量表和宾夕法尼亚大学犬短暂疼痛量表评分，并通过力平台确定峰值垂直力（PVF）。治疗组给予镇静治疗，取血（55 mL）。血小板通过使用点过滤器回收，并在30分钟内注射到关节内。对照组给予镇静，关节内注射生理盐水（0.9% NaCl）溶液。在注射血小板或生理盐水12周后再次进行评估。结果：狗的体重在18.3到63.9公斤（40.3到140.6磅）之间，年龄在1.5到8岁之间。对于对照犬，第12周的跛行评分、疼痛评分和PVF与预处理值无显著差异。相比之下，对于接受血小板注射的狗，与预处理值相比，12周后跛行评分（中位评分降低55%）、疼痛评分（中位评分降低53%）和PVF（平均PVF增加12%）显著改善。结论和临床意义：结果表明，单次关节内注射自体血小板可显著改善单关节骨关节炎犬的病情。
Objective-To determine efficacy of a single intra-articular injection of an autologous platelet concentrate for treatment of osteoarthritis in dogs.Design-Randomized, controlled, 2-center clinical trial.Animals-20 client-owned dogs with osteoarthritis involving a single joint.Procedures-Dogs were randomly assigned to a treatment or control group. In all dogs, severity of lameness and pain was scored by owners with the Hudson visual analog scale and the University of Pennsylvania Canine Brief Pain Inventory, respectively, and peak vertical force (PVF) was determined with a force platform. Dogs in the treatment group were then sedated, and a blood sample (55 mL) was obtained. Platelets were recovered by means of a point-of-use filter and injected intra-articularly within 30 minutes. Control dogs were sedated and given an intra-articular injection of saline (0.9% NaCl) solution. Assessments were repeated 12 weeks after injection of platelets or saline solution.Results-Dogs weighed between 18.3 and 63.9 kg (40.3 and 140.6 lb) and ranged from 1.5 to 8 years old. For control dogs, lameness scores, pain scores, and PVF at week 12 were not significantly different from pretreatment values. In contrast, for dogs that received platelet injections, lameness scores (55% decrease in median score), pain scores (53% decrease in median score), and PVF (12% increase in mean PVF) were significantly improved after 12 weeks, compared with pretreatment values.Conclusions and Clinical Relevance-Results suggested that a single intra-articular injection of autologous platelets resulted in significant improvements at 12 weeks in dogs with osteoarthritis involving a single joint.