Exhaled nitric oxide concentrations: Online versus offline values in healthy children
Exhaled nitric oxide concentrations: Online versus offline values in healthy children
复制标题
DOI：
10.1002/ppul.10023
复制
发表时间：
2002-04-01
影响因子：
3.1
通讯作者：
Silkoff, PE
中科院分区：
文献类型：
--
作者：
Kissoon, N;Duckworth, LJ;Silkoff, PE
呼出气一氧化氮（FENO）是一种无创和实用的方法来评估气道炎症。我们进行这项调查，以确定最合适的流速来测量FENO，并获得儿童FENO的参考值。使用荧光一氧化氮分析仪在4种呼气流速（46、31、23和15 mL/sec）下测量112名6-18岁健康儿童（60名男性）的FENO。结果表明：（1）FENO与呼气流速的组内相关系数在离线值范围为0.92-0.99，在线值范围为0.99; 2）呼气流速为46 mL/sec时的变化（SD，9.39）显著低于其他流速，尤其是在15 mL/sec时（SD，26.55）3）对于离线和在线值，FENO随着流量的减小而增大; 4）在31和46 mL/s呼气流量下，离线袋和在线FENO值之间没有显著差异并且具有良好的一致性; 5）多元回归分析显示，FENO的显著预测因素为血流量、体表面积、年龄，和FEF 25 - 75。我们提供了健康儿童的FENO值，并提出使用单次呼吸技术测量儿童FENO的理想呼气流速为30- 75。50 mL/sec。(C)2002 Wiley-Liss，Inc.
Exhaled nitric oxide (FENO) is a noninvasive and practical method to assess airway inflammation. We conducted this investigation to determine the most appropriate flow rate to measure FENO and to obtain reference values for FENO in children. FENO was measured in 112 healthy 6-18 year olds (60 males) at 4 expiratory flow rates (46, 31, 23, and 15 mL/sec) using a chemiluminescent nitric oxide analyzer. Offline and online analyses were done to determine FENO intraclass correlation coefficients, the relationship between FENO and expiratory flow rates, and the effects of age and gender on these measurements.The major findings were: 1) intraclass correlation coefficients for FENO and flow rates ranged from 0.92-0.99 for offline values, and 0.99 for all online values; 2) variation at an expiratory flow rate of 46 mL/sec (SD, 9.39) was considerably less than at other flows, especially at 15 mL/sec (SD, 26.55); 3) FENO increased as flow rates decreased for both offline and online values; 4) there were no significant differences and good agreement between offline bag and online FENO) values at 31 and 46 mL/sec expiratory flows; and 5) using multiple regression, significant predictors of FENO were flow, body surface area, age, and FEF25-75.We have provided FENO values in healthy children and propose that the ideal expiratory flow rate for FENO measurements in children using the single breath technique is between 30-50 mL/sec. (C) 2002 Wiley-Liss, Inc.