Annulation of pyrrole: application to the synthesis of indolizidine alkaloids
Annulation of pyrrole: application to the synthesis of indolizidine alkaloids
复制标题
DOI：
10.1016/j.tet.2005.06.026
复制
发表时间：
2005-08-22
期刊：
影响因子：
2.1
通讯作者：
Sprod, OR
中科院分区：
文献类型：
--
作者：
Amos, RIJ;Gourlay, BS;Sprod, OR
吡咯的亲核性已被用于快速组装吲哚里西啶生物碱的双环骨架。关键序列是从γ-内酯到吡咯上的第二个环的环化，并且已经在天然产物monomorine和（+/-）-indolizidine 209 D的合成中被利用。(c)2005爱思唯尔有限公司保留所有权利。
The nucleophilicity of pyrrole has been exploited to rapidly assemble the bicyclic skeleton of the indolizidine alkaloids. The key sequence is the annulation of a second ring onto pyrrole from a gamma-lactone and has been exploited in the synthesis of the natural products monomorine and (+/-)-indolizidine 209D. (c) 2005 Elsevier Ltd. All rights reserved.