Delusional unipolar depression: description and drug response.
Delusional unipolar depression: description and drug response.
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妄想性单相抑郁：描述和药物反应。
DOI：
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发表时间：
1978
影响因子：
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通讯作者：
M. Bowers
中科院分区：
文献类型：
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作者：
J. Nelson;M. Bowers
本回顾性研究描述了13例妄想性单相抑郁症患者对抗精神病药-三环类抗抑郁药联合治疗的反应。研究诊断标准由两名独立的评估者使用，以验证是否存在妄想性、原发性、单相、重度抑郁障碍。13例患者符合标准，并接受抗精神病-抗抑郁药物联合治疗。13人中有12人回答。这与单独使用三环类抗抑郁药治疗妄想性抑郁症的低应答率形成鲜明对比。妄想性抑郁症的描述特征进行了比较，一组非妄想性单相抑郁症。妄想性抑郁症患者有更多的抑郁发作史，更多的妄想性抑郁症患者表现出精神障碍。
This retrospective study describes the response of 13 delusional unipolar depressives to combination antipsychotic-tricyclic antidepressant drug therapy. The Research Diagnostic Criteria were used by two independent raters to verify the presence of a delusional, primary, unipolar, major depressive disorder. Thirteen patients met the criteria and received combined antipsychotic-antidepressant pharmacotherapy. Twelve of the 13 responded. This contrasts sharply with the low response rate described for delusional depressives when treated with tricyclic antidepressants alone. Descriptive characteristics of the delusional depressives were compared with those of a group of nondelusional unipolar depressives. Delusional depressives had histories of a greater number of prior depressive episodes and more of the delusional depressives demonstrated a psychomotor disturbance.