Steroid hormone secretion from a virilizing lipoid cell tumor of the ovary.
Steroid hormone secretion from a virilizing lipoid cell tumor of the ovary.
复制标题
卵巢男性化类脂细胞瘤分泌类固醇激素。
作者：
J. Imperato;R. E. Peterson;M. Dawood;M. Zullo;E. Kramer;B. Saxena;A. Arthur;T. Huang
作者报告的情况下，一个23岁的妇女与男性化的脂肪细胞瘤的卵巢。患者在4岁时发生性早熟，从5岁至10岁每周接受醋酸甲羟孕酮肌内注射治疗。她在13岁时开始自发性排卵，但在15岁时出现多毛、痤疮和月经不规律，随后在20岁时继发闭经。类固醇分析显示外周血浆睾酮、双氢睾酮、雄烯二酮、17 α-羟孕酮、孕酮、脱氧皮质酮、雌酮和雌二醇水平升高。肾上腺和卵巢静脉导管插入术显示右卵巢静脉睾酮、脱氢表雄酮、雄烯二酮、17 α-羟孕酮、孕酮、脱氧皮质酮和皮质酮、11-脱氧皮质醇、皮质醇、雌酮和雌二醇的分泌增加。手术切除了右侧卵巢脂肪细胞瘤。肿瘤组织的孵育研究证实了性腺和肾上腺皮质类固醇的存在。该组织还含有高亲和力的人绒毛膜促性腺激素-促黄体激素结合位点，具有正常的结合亲和力。
The authors report the case of a 23-year-old woman with a virilizing lipoid cell tumor of the ovary. The patient developed precocious puberty at age 4 and from age 5 to 10 years was treated weekly with intramuscular medroxyprogesterone acetate. She began to menstruate spontaneously at age 13, but developed hirsutism, acne, and irregular menses at age 15 followed by secondary amenorrhea at age 20. Steroid analyses demonstrated elevated peripheral plasma levels of testosterone, dihydrotestosterone, androstenedione, 17 alpha-hydroxyprogesterone, progesterone, desoxycorticosterone, estrone, and estradiol. Catheterization of the adrenal and ovarian veins revealed increased secretion of testosterone, dehydroepiandrosterone, androstenedione, 17 alpha-hydroxyprogesterone, progesterone, desoxycortcosterone, and corticosterone, 11-desoxycortisol, cortisol, estrone, and estradiol from the right ovarian vein. At surgery a right ovarian lipoid cell tumor was removed. Incubation studies with the tumor tissue confirmed the presence of gonadal and adrenocortical steroids. The tissue also contained high-affinity human chorionic gonadotropin-luteinizing hormone binding sites with normal binding affinity.