Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjogren's syndrome
Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjogren's syndrome
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DOI：
10.1007/s10875-005-4091-5
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发表时间：
2005-05-01
影响因子：
9.1
通讯作者：
Skarstein, K
中科院分区：
文献类型：
--
作者：
Jonsson, MV;Szodoray, P;Skarstein, K
B细胞活化因子（BAFF）和增殖诱导配体（APRIL）是肿瘤坏死因子超家族的成员。我们研究了循环BAFF和APRIL与慢性自身免疫性疾病干燥综合征唾液腺中的血清学偏差和淋巴组织的关系。在130例连续小涎腺活检中，33例发现异位生发中心形状的类肉瘤组织，与病灶评分增加和血清IgG水平升高一致。滤泡树突状细胞网络，单核细胞增殖和改变B/T细胞比例也分开了两个亚群。与健康献血者相比，Sjogren综合征患者的sBAFF和sAPRIL血清水平升高，尤其是在抗Ro/La+患者中。虽然这些差异可能与生发中心的形成无关，但sBAFF和sAPRIL、病灶评分和IgG之间的正相关表明它们在原发性干燥综合征的疾病进展中可能起作用。
B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are members of the tumour necrosis factor superfamily. We have examined circulating BAFF and APRIL in relation to serological deviations and lymphoid organization in the salivary glands of the chronic, autoimmune disorder Sjogren's syndrome. Lymphoid organization in the shape of ectopic germinal centers were detected in 33 of 130 consecutive minor salivary gland biopsies and coincided with increased focus score and elevated levels of serum IgG. Follicular dendritic cell networks, proliferation of mononuclear cells and altered B/T cell ratio also separated the two subgroups. Serum levels of sBAFF and sAPRIL were increased in Sjogren's syndrome compared to healthy blood donors, especially in anti-Ro/La+ patients. Though the differences could not be related to germinal center formation, positive correlations between serum levels of sBAFF and sAPRIL, focus score and IgG denotes their possible role in the disease progression of primary Sjogren's syndrome.