Endocrine disruptors, environmental oxygen, epigenetics and pregnancy.
Endocrine disruptors, environmental oxygen, epigenetics and pregnancy.
复制标题
DOI：
10.2741/e279
复制
发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Sharma SS
中科院分区：
文献类型：
--
作者：
Robins JC;Marsit CJ;Padbury JF;Sharma SS
胎盘及其无数的功能是成功繁殖的核心。这些功能会受到孕期环境的影响。这种影响可以改变适当的遗传程序，以允许持续怀孕和适当的胎儿发育。这种编程的改变可能是由与环境暴露有关的表观遗传改变引起的。表观遗传改变现在被认为与几种重要的生殖结果有关，包括早孕流产、宫内生长受限、先天性综合征(例如。贝克维斯-魏德曼综合征)，早产和先兆子痫。与不利生殖影响有关的环境暴露的多样性继续增加。许多注意力都集中在内分泌干扰物和其他外源性药物在不孕症中的作用上，但最近的研究表明，这些化学物质也可能对怀孕和发育产生不利影响。环境中的氧气对妊娠早期的成功也是至关重要的。在其他影响中，氧气水平的改变和胎盘之间有明显的联系。随着研究不断增加我们对包括影响妊娠的表观遗传调控在内的分子过程的理解，具体研究广义的环境如何在改变这些关键功能方面发挥作用将是至关重要的。
The placenta and its myriad functions are central to successful reproductive outcomes. These functions can be influenced by the environment encountered throughout pregnancy. Such influences can alter the appropriate genetic programming needed to allow for sustained pregnancy and appropriate fetal development. This altered programming may result from epigenetic alterations related to environmental exposures. Epigenetic alterations are now being linked to several important reproductive outcomes, including early pregnancy loss, intrauterine growth restriction, congenital syndromes (eg. Beckwith-Weidemann syndrome), preterm birth and preeclampsia. The diversity of environmental exposures linked to adverse reproductive effects continues to grow. Much attention has focused on the role of endocrine disruptors and other xenobiotics in infertility, but recent work is demonstrating that these chemicals may have adverse effects in pregnancy and development as well. Environmental oxygen is also critical in early pregnancy success. There are clear links between altered oxygen levels and placentation amongst other effects. As research continues to increase our understanding of the molecular processes including epigenetic regulation that influence pregnancy, it will be critical to specifically examine how the environment, broadly defined, may play a role at altering these critical functions.