Animal models of cancer pain.
Animal models of cancer pain.
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DOI：
10.1007/978-1-60761-880-5_8
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发表时间：
2008-06
影响因子：
0.8
通讯作者：
C. Pacharinsak;A. Beitz
中科院分区：
文献类型：
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作者：
C. Pacharinsak;A. Beitz
癌症疼痛的发生率在晚期疾病患者以及正在接受实体瘤积极治疗的患者中很高。此外，现代癌症疗法显著提高了存活率，使得有效的疼痛控制变得至关重要，因为未缓解的疼痛显著降低了这些患者的生活质量。因此，疼痛管理的目标不仅是减轻疼痛，而且还要维持患者的正常生活质量。为了应对这一挑战，需要具有更大疗效但副作用更少的新型镇痛剂来缓解癌症引起的疼痛。最近在理解癌症疼痛机制方面的进展得到了几种啮齿动物模型的发展的帮助，这些模型表明存在独特的肿瘤诱导的中枢和外周解剖学和病理生理学变化，以及神经、周围组织和肿瘤细胞之间的物理和生化相互作用，理解这些对于开发癌症相关疼痛的更好治疗策略可能很重要。本文综述了骨癌疼痛模型、非骨癌疼痛模型、癌症侵袭疼痛模型、癌症化疗诱导的周围神经病变和自发性癌症疼痛模型，所有这些模型都有助于更好地理解肿瘤诱导疼痛的基础，并允许探索新的基于机制的治疗方法。
The incidence of cancer pain is high in patients with advanced disease as well as in patients undergoing active treatment for solid tumors. Further, modern cancer therapies have significantly increased survival rates, making effective pain control critical as unrelieved pain significantly decreases the quality of life of such patients. Thus, the goal of pain management is to not only alleviate pain, but also maintain the patient’s normal quality of life. To meet this challenge, novel analgesics with greater efficacy but fewer side effects are needed for alleviating cancer-induced pain. Recent advances in understanding the mechanism(s) of cancer pain have been assisted by the development of several rodent models that have shown that there are unique tumor-induced central and peripheral anatomical and pathophysiological changes, as well as physical and biochemical interactions between nerves, surrounding tissue, and tumor cells, which may be important to understand in order to develop better treatment strategies for cancer-associated pain. This review focuses on bone cancer pain models, nonbone cancer pain models, cancer invasion pain models, cancer chemotherapeutic-induced peripheral neuropathy, and spontaneous-occurring cancer pain models, all of which have contributed to a better understanding of the basis for tumor-induced pain and have allowed exploration of novel mechanistic-based therapies.