The tumor-enhancing principles of Croton tiglium L.
The tumor-enhancing principles of Croton tiglium L.
复制标题
Croton tigliium L 的肿瘤增强原理。
作者：
L. B.;Van;Duuren;L. Langseth;A.;Sivak;L. Orris
从巴豆种子中提取分离出2种活性辅致癌物质。并描述了它们的长期生物学测试。这两种物质在非常低的剂量下都是强有力的致癌物。还报道了活性物质的化学转化衍生物的生物活性。肉豆蔻酸佛波酯乙酸酯是一种从巴豆树脂中分离得到的半合成化合物，具有显著的促进活性。活性材料的化学的一些方面进行了讨论。
Summary The extraction and isolation of 2 active cocarcinogenic agents from the seed of Croton tiglium L. and their long-term biologic testing are described. Both materials are potent cocarcinogens at very low dosages. The biologic activity of chemically transformed derivatives of the active materials is also reported. Phorbol myristate acetate, a semisynthetic compound derived from croton resin, showed notable promoting activity. Some aspects of the chemistry of the active materials are discussed.