FGF2 and IL-1β - explorers of unconventional secretory pathways at a glance
FGF2 and IL-1β - explorers of unconventional secretory pathways at a glance
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DOI：
10.1242/jcs.250449
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发表时间：
2020-11-01
影响因子：
4
通讯作者：
Nickel, Walter
中科院分区：
文献类型：
--
作者：
Pallotta, Maria Teresa;Nickel, Walter
成纤维细胞生长因子2（FGF 2）和白细胞介素1 β（IL-1 β）是具有细胞外功能的蛋白质亚类的最早的例子之一，它们被发现缺乏N-末端分泌信号肽，并被证明以ER和高尔基体非依赖性方式分泌。许多年后，已经发现了许多替代的分泌途径，统称为非常规蛋白质分泌（UPS）的过程。在这些研究过程中，发现FGF 2和IL-1 β的非常规分泌基于不同的途径、机制和分子机制。在简要介绍了介导蛋白质非常规分泌和跨细胞扩散的各种途径之后，这篇Cell Science at a Glance海报文章旨在重点分析最近的关键发现，提供有关驱动FGF 2和IL-1 β分泌的分子机制和机制的前所未有的细节。这些发现也与其他非常规分泌的货物高度相关，如FGF 2和IL 1 β，在生物医学相关过程中发挥基本的生物学功能，如肿瘤诱导的血管生成和炎症。
Fibroblast growth factor 2 (FGF2) and interleukin 1 beta (IL-1 beta) were among the earliest examples of a subclass of proteinswith extracellular functions that were found to lack N-terminal secretory signal peptides and were shown to be secreted in an ER- and Golgi-independent manner. Many years later, a number of alternative secretory pathways have been discovered, processes collectively termed unconventional protein secretion (UPS). In the course of these studies, unconventional secretion of FGF2 and IL-1 beta were found to be based upon distinct pathways, mechanisms and molecular machineries. Following a concise introduction into various pathways mediating unconventional secretion and transcellular spreading of proteins, this Cell Science at a Glance poster article aims at a focused analysis of recent key discoveries providing unprecedented detail about the molecular mechanisms and machineries driving FGF2 and IL-1 beta secretion. These findings are also highly relevant for other unconventionally secreted cargoes that, like FGF2 and IL1 beta, exert fundamental biological functions in biomedically relevant processes, such as tumor-induced angiogenesis and inflammation.