Genetic covariation of neuroticism with monoamine oxidase activity and smoking
Genetic covariation of neuroticism with monoamine oxidase activity and smoking
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DOI：
10.1002/ajmg.1555
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发表时间：
2001-12-08
期刊：
影响因子：
--
通讯作者：
Martin, NG
中科院分区：
文献类型：
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作者：
Kirk, KM;Whitfield, JB;Martin, NG
众所周知，神经质人格特质的变异受到遗传影响，但尽管进行了一些相关研究，但所涉及的基因尚未得到表征。在最近一项针对1,551名双胞胎受试者的血小板单胺氧化酶研究中，我们发现单胺氧化酶活性与艾森克人格问卷神经质量表得分之间存在显著相关性。进一步的分析表明，神经质和单胺氧化酶活性与吸烟习惯的变化，并调整吸烟的影响加强了MAO和神经质之间的关联。神经质，吸烟和单胺氧化酶活性之间的协变的遗传和环境来源的分析表明，约8%的神经质的遗传变异是由于相同的加性遗传效应，有助于单胺氧化酶活性的变化，这表明神经质的变化与5-羟色胺代谢的方面。(C)2001 Wiley-Liss，Inc.
Variation in the personality trait of neuroticism is known to be affected by genetic influences, but despite a number of association studies, the genes involved have not yet been characterized. In a recent study of platelet monoamine oxidase in 1,551 twin subjects, we found a significant association between monoamine oxidase activity and scores on the Eysenck Personality Questionnaire neuroticism scale. Further analyses presented here indicate that both neuroticism and monoamine oxidase activity are associated with variation in smoking habits, and that adjusting for the effect of smoking strengthens the association between MAO and neuroticism. Analysis of the genetic and environmental sources of covariation between neuroticism, smoking, and monoamine oxidase activity show that approximately 8% of the genetic variance in neuroticism is due to the same additive genetic effects that contribute to variation in monoamine oxidase activity, suggesting that variation in neuroticism is associated in part with aspects of serotonin metabolism. (C) 2001 Wiley-Liss, Inc.