Acylation of alcohols and amines with vinyl acetates catalyzed by Cp*Sm-2(thf)(2)
Acylation of alcohols and amines with vinyl acetates catalyzed by Cp*Sm-2(thf)(2)
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DOI：
10.1021/jo952168m
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发表时间：
1996-05-03
影响因子：
3.6
通讯作者：
Sakaguchi, S
中科院分区：
文献类型：
--
作者：
Ishii, Y;Takeno, M;Sakaguchi, S
Cp*Sm-2（thf）（2）是一种有效的催化剂，在温和的条件下可催化醇、胺与酯的酰化反应。在本酰化反应中，醋酸乙烯酯和醋酸异丙烯酯是较好的酰化剂。因此，在Cp*Sm-2（thf）（2）存在下，各种醇和胺与乙酸乙烯酯和乙酸异丙烯酯进行酰化，以良好至优异的产率得到相应的酯和酰胺。醇和胺的这种催化酰化提供了另外一种有用的方法，即在非常温和的条件下使用各种酯代替酸酐和酰氯作为酰化剂。
Cp*Sm-2(thf)(2) was found to be an efficient catalyst for the acylation of alcohols and amines with esters under mild conditions. In the present acylation, vinyl and isopropenyl acetates served as good acylating agents. Thus, a variety of alcohols and amines underwent acylation with vinyl and isopropenyl acetates in the presence of Cp*Sm-2(thf)(2) to give the corresponding esters and amides in good to excellent yields. This catalytic acylation of alcohols and amines offers an additional useful method by the use of various esters, instead of acid anhydrides and acid chlorides, as acylating agents under very mild conditions.