Soluble vascular endothelial growth factor receptor-1 in intrauterine growth restricted fetuses and neonates
Soluble vascular endothelial growth factor receptor-1 in intrauterine growth restricted fetuses and neonates
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DOI：
10.1016/j.earlhumdev.2005.09.010
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发表时间：
2006-04-01
影响因子：
2.5
通讯作者：
Hassiakos, Dimitrios
中科院分区：
文献类型：
--
作者：
Boutsikou, Theodora;Malamitsi-Puchner, Ariadne;Hassiakos, Dimitrios
背景：胎儿宫内生长受限（IUGR）时血管生成改变，血管生成是生长发育的关键过程。血管内皮生长因子（vascular endothelial growth factor，VEGF）及其受体VEGFR-1、可溶性VEGFR-1和VEGFR-2是生理性和病理性血管生成所必需的调节系统。25例IUGR和15例适合胎龄（阿加）的足月胎儿和新生儿及其母亲被纳入研究。结局指标：通过酶免疫测定法测定以下血清中的sVEGFR-1水平：母亲（MS）、代表胎儿状态的脐带（UC）和出生后第1天（N1）和第4天（N4）的新生儿。IUGR组MS、UC、N1和N4 sVEGFR-1水平显著高于相应的阿加病例（分别为p=0.005、p=0.026、p=0.005和p=0.017）。在IUGR和阿加组中，母亲sVEGFR-1水平显著高于胎儿和新生儿水平（所有病例p < 0.001）。IUGR组和阿加组从UC到N4的Tatter均显著降低（P < 0.01）。MS、NI和N4 sVEGFR-1水平与婴儿的定制百分位数呈负相关[（r=-0.489，p =0.001），（r=-0.440，p =0.004），（r=-0.431，p =0.006）]。结论：IUGR组sVEGFR-1水平高于阿加组，可能反映了IUGR中存在的抗血管生成机制的优势。sVEGFR-1水平从UC至N4的降低可能代表生长和发育的子宫外启动，因此代表血管生成机制的流行。(c)2005 Elsevier爱尔兰有限公司所有。rights reserved.
Background: Angiogenesis, a critical process for growth and development is altered in intrauterine growth restriction (IUGR). Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1, soluble (s) VEGFR-1 and VEGFR-2 represent a regulatory system, essential for both physiological and pathological angiogenesis.Aim: To study the implication of sVEGFR-1-a VEGF antagonist-in IUGR.Study design: Prospective study.Methods: Twenty-five IUGR and 15 appropriate for gestational age (AGA) full-term fetuses and neonates with their mothers were included in the study. Outcome measures: sVEGFR-1 levels were determined by enzyme immunoassay in the serum of: mothers (MS), umbilical cords (UC)-representing fetal state-and neonates on day 1 (N1) and 4 (N4) of life.Results: MS, UC, N1 and N4 sVEGFR-1 levels in IUGR were significantly higher compared to respective AGA cases (p=0.005, p=0.026, p=0.005 and p=0.017, respectively). In IUGR and AGA groups, maternal sVEGFR-1 levels were significantly higher than fetal and neonatal levels (p in all cases < 0.001). The tatter presented in both IUGR and AGA groups a significant decrease from UC to N4 (p in all cases < 0.01). MS, NI and N4 sVEGFR-1 levels negatively correlated with the infants' customized centiles [(r=-0.489, p=0.001), (r=-0.440, p=0.004), (r=-0.431, p=0.006), respectively].Conclusions: Higher sVEGFR-1 levels in the IUGR as compared to the AGA group possibly reflect the predominance of antiangiogenic mechanisms present in IUGR. The decrease of sVEGFR-1 levels from UC to N4 may represent ex utero initiation of growth and development and therefore, prevalence of angiogenic mechanisms. (c) 2005 Elsevier Ireland Ltd. All. rights reserved.