Brain Pathways in Blood Pressure Regulation.
Brain Pathways in Blood Pressure Regulation.
复制标题
血压调节的大脑通路。
DOI：
10.1161/hypertensionaha.123.21723
复制
发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Abbott,StephenBG
中科院分区：
文献类型：
--
作者：
Stocker,SeanD;Ferreira,CarolineB;Souza,GeorgeMPR;Abbott,StephenBG
神经源性高血压是指由自主神经或更具体地说，交感神经系统介导的动脉血压(ABP)的慢性升高。交感神经过度活跃或交感神经功能改变在实验模型和人类高血压的发生、维持和病理生理学中起着重要作用。1，2在过去的几十年里，一个主要的研究重点已经确定了调节静息和高血压时交感神经活动(SNA)和ABP的关键脑区和特定细胞群。本文的目的是简要讨论这些发现。鉴于主题的广度，重要的主题如内脏传入(压力感受器和化学感受器)、脑肾素-血管紧张素系统、氧化应激和神经免疫相互作用将在其他地方讨论。
Neurogenic hypertension refers to a chronic increase in arterial blood pressure (ABP) mediated by the autonomic, or more specifically, sympathetic nervous system. Sympathetic hyperactivity or altered sympathetic function contributes to the development, maintenance, and pathophysiology of hypertension in both experimental models and humans. 1, 2 Over the last several decades, a major research focus has identified key brain regions and specific cell groups that regulate sympathetic nerve activity (SNA) and ABP at rest and in hypertension. The purpose of this article is to briefly discuss such discoveries. Given the breadth of the topic, important topics such as the visceral afferents (baroreceptors and chemoreceptors), brain renin–angiotensin system, oxidative stress, and neuroimmune interactions will be discussed elsewhere.