Progesterone Prevents Sleep Disturbances and Modulates GH, TSH, and Melatonin Secretion in Postmenopausal Women
Progesterone Prevents Sleep Disturbances and Modulates GH, TSH, and Melatonin Secretion in Postmenopausal Women
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DOI：
10.1210/jc.2010-2558
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发表时间：
2011-04-01
影响因子：
5.8
通讯作者：
Copinschi, Georges
中科院分区：
文献类型：
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作者：
Caufriez, Anne;Leproult, Rachel;Copinschi, Georges
背景：许多神经活性孕酮代谢物产生镇静样作用。然而，孕激素管理对睡眠的影响还没有很好的characteristic.Objective：探讨一个3周的孕激素管理对睡眠结构和多种激素profiles.Subjects的影响：八个健康的绝经后妇女，48-74岁，没有睡眠投诉或血管痉挛症状。没有人接受激素替代疗法。研究设计：随机双盲安慰剂对照研究。为期3周，受试者每天在2300 h服用300 mg黄体酮或安慰剂胶囊。睡眠多导记录在过去的两个晚上，并在15分钟的时间间隔为24小时获得血液样本。结果：在第一个晚上（没有血液采样），睡眠是相似的，在这两个条件。在安慰剂组中，采血过程与明显的睡眠障碍有关，而孕酮治疗组的睡眠障碍明显减少：与安慰剂组相比，孕酮治疗组入睡后的平均清醒时间减少53%，慢波睡眠时间增加近50%，总慢波活动（反映深度睡眠的持续时间和强度）增加近45%（P
Context: A number of neuroactive progesterone metabolites produce sedative-like effects. However, the effects of progesterone administration on sleep are not well characterized.Objective: To investigate the effects of a 3-wk progesterone administration on sleep architecture and multiple hormonal profiles.Subjects: Eight healthy postmenopausal women, 48-74 yr old, without sleep complaints or vasomotor symptoms. None was on hormone replacement therapy. They did not take any medication for >= 2 months.Design: Randomized, double-blind, placebo-controlled study. For 3 wk, subjects took daily at 2300 h a capsule of either 300 mg of progesterone or placebo. Sleep was polygraphically recorded during the last two nights, and blood samples were obtained at 15-min intervals for 24 h.Results: During the first night (no blood sampling), sleep was similar in both conditions. Under placebo, blood sampling procedure was associated with marked sleep disturbances, which were considerably reduced under progesterone treatment: mean duration of wake after sleep onset was 53% lower, slow-wave sleep duration almost 50% higher, and total slow-wave activity (reflecting duration and intensity of deep sleep) almost 45% higher under progesterone than under placebo (P