Alteration in cellular morphology, density and distribution in rat vocal fold mucosa following injury
Alteration in cellular morphology, density and distribution in rat vocal fold mucosa following injury
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DOI：
10.1111/j.1524-475x.2009.00550.x
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发表时间：
2010-01-01
影响因子：
2.9
通讯作者：
Welham, Nathan V.
中科院分区：
文献类型：
--
作者：
Ling, Changying;Yamashita, Masaru;Welham, Nathan V.
声带粘膜在发声中起着重要作用。其细胞组成和密度在各种病理条件下经常变化，通常导致细胞外基质产生，组织粘弹性和声音质量的改变。在这项研究中，细胞的变化，在大鼠粘膜后，单侧剥离损伤进行了调查和半定量分析。在损伤后的粘膜中观察到细胞形态、组成和密度的独特和顺序的变化。细胞募集是损伤早期的主要事件，并在损伤后第5天达到高峰。几种类型的细胞，包括嗜中性粒细胞样细胞，上皮细胞和成纤维细胞样细胞，依次招募。损伤和随后的粘膜重建后反应性细胞群的连续出现表明它们参与了声带组织修复和疤痕形成过程。
The vocal fold mucosa plays an important role in voice production. Its cellular composition and density frequently change under various pathological conditions, often contributing to altered extracellular matrix production, tissue viscoelasticity, and voice quality. In this study, cellular changes in the rat mucosa following a unilateral stripping injury were investigated and analyzed semi-quantitatively. Distinctive and sequential changes in cellular morphology, composition, and density were observed in the mucosa post-injury. Cellular recruitment was a major event during the early stage of injury and reached its peak level by day 5 post-injury. Several types of cells, including neutrophil-like cells, epithelial cells, and fibroblast-like cells, were sequentially recruited. The sequential emergence of reactive cell populations following injury and subsequent reconstruction of the mucosa suggests their involvement in vocal fold tissue repair and scar formation processes.