Naloxone Effectiveness
Naloxone Effectiveness
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DOI：
10.1097/jan.0000000000000230
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发表时间：
2018-07-01
影响因子：
1.5
通讯作者：
Moleta, Yvette
中科院分区：
文献类型：
--
作者：
Chimbar, Lisa;Moleta, Yvette
目的：阿片类药物滥用和过量是一个公共卫生问题，因为它与发病率和死亡率增加有关。本系统综述的重点是纳洛酮带回家计划的应用及其与阿片类药物滥用者死亡率降低的相关性。带回家的纳洛酮计划包括分发的纳洛酮试剂盒和相应的过量识别教育。本系统评价的目的是确定是否提供带回家的纳洛酮的程序是有效的，防止致命的过量滥用阿片类药物。方法：在学术搜索完成，CINHAL，MEDLINE，PsychINFO和SocINDEX进行系统搜索。搜索的关键词是“程序”、“带回家的工具包”、“纳洛酮”、“纳洛酮”和“死亡率”。根据预先确定的纳入和排除标准，我们发现了9项研究可供纳入。结果：然后对研究结果进行了定性合成，在当前的研究中，有压倒性的支持，即带回家的纳洛酮方案在预防致命的阿片类药物过量方面是有效的。一个显着的局限性，这一系统的审查是缺乏随机对照试验，因为它被视为不道德的扣留已知的救命药物从高危population.Practice影响：在最新的证据的基础上，有压倒性的支持，带回家的纳洛酮程序与那些滥用阿片类药物的死亡率降低。因此，有一个实践的变化，带回家纳洛酮计划应该在整个社区更广泛地实施，作为降低与阿片类药物过量相关的死亡率的方法。建议进一步研究这些方案的成本效益。
Purpose: Opioid abuse and overdose is a public health concern as it relates to increased morbidity and mortality. This systematic review focuses on the application of take-home naloxone programs and its association with decreased mortality among those who abuse opioids. Take-home naloxone programs consist of distributed naloxone kits and corresponding education of overdose recognition. The purpose of this systematic review was to determine if programs that supply take-home naloxone are effective in preventing fatal overdoses among those who abuse opioids.Methods: A systematic search was conducted in Academic Search Complete, CINHAL, MEDLINE, PsychINFO, and SocINDEX. The key words searched were "programs,'' "take-home kits,'' "Narcan,'' "Naloxone,'' and "mortality.'' On the basis of the predefined inclusion and exclusion criteria, nine studies were found for inclusion.Results: Study results were then synthesized, qualitatively, and within the current research, there is overwhelming support of take-home naloxone programs being effective in preventing fatal opioid overdoses. A significant limitation of this systematic review is the lack of randomized controlled trials as it is viewed as unethical withholding a known lifesaving medication from an at-risk population.Practice Implications: On the basis of the most current evidence, there is overwhelming support of take-home naloxone programs associated with decreased mortality among those who abuse opioids. As a result, there is an implication for a practice change that take-home naloxone programs should be more widely implemented throughout communities as amethod of decreasing mortality associated with opioid overdoses. It is recommended that further research is done examining the cost- effectiveness of these programs.