An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients.
An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients.
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DOI：
10.1002/ijc.31785
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发表时间：
2018-12-01
影响因子：
6.4
通讯作者：
Verhoeven RHA
中科院分区：
文献类型：
--
作者：
Brouwer NPM;Bos ACRK;Lemmens VEPP;Tanis PJ;Hugen N;Nagtegaal ID;de Wilt JHW;Verhoeven RHA
关于结直肠癌（CRC）诊断过程和治疗的持续变化，重要的是要评估长期趋势，这与癌症患者护理的进一步研究和创新有关。本研究的目的是分析荷兰诊断为CRC患者的发病率，治疗和生存率的发展。对于这项基于人群的回顾性队列研究，使用全国范围内基于人群的荷兰癌症登记处的数据（n = 267，765）确定了1989年至2014年期间在荷兰诊断为CRC的所有患者，随访至2016年1月1日。对发病率、死亡率、分期分布、治疗和从诊断时起测量的相对生存率的趋势进行分析。结肠癌和直肠癌的发病率都有所上升。III期结肠癌术后化疗的使用增加（14-60%），直肠癌术前（化疗）放疗的使用增加（2-66%）。IV期疾病患者的全身治疗和膀胱切除术增加。结肠癌的5年相对生存率从53%显著增加到62%，直肠癌从51%增加到65%。治疗的不断进步，以及CRC患者护理中其他因素的改善-例如诊断，专门的手术和术前和术后护理-导致CRC患者相对生存率的持续改善。随着结直肠癌发病率的不断上升，应加强筛查工作，密切监测筛查效果。 有什么新消息吗？ 为了最好地为癌症管理提供新的方向，研究历史趋势很重要。在这里，作者分析了荷兰25年来关于结直肠癌发病率、治疗和生存率的数据。在1989年至2014年期间，发病率和5年相对生存率都有所增加。某些治疗也变得更加普遍，如III期患者的术后化疗和IV期患者的全身治疗和手术切除转移瘤。改进的诊断和治疗帮助更多患者存活，CRC发病率的上升支持荷兰政府在2014年推出的全国筛查计划的使用。
Regarding the continuous changes in the diagnostic process and treatment of colorectal cancer (CRC), it is important to evaluate long‐term trends which are relevant in giving direction for further research and innovations in cancer patient care. The aim of this study was to analyze developments in incidence, treatment and survival for patients diagnosed with CRC in the Netherlands. For this population‐based retrospective cohort study, all patients diagnosed with CRC between 1989 and 2014 in the Netherlands were identified using data of the nationwide population‐based Netherlands Cancer Registry (n = 267,765), with follow‐up until January 1, 2016. Analyses were performed for trends in incidence, mortality, stage distribution, treatment and relative survival measured from the time of diagnosis. The incidence of both colon and rectal cancer has risen. The use of postoperative chemotherapy for Stage III colon cancer increased (14–60%), as well as the use of preoperative (chemo)radiotherapy for rectal cancer (2–66%). The administration of systemic therapy and metastasectomy increased for Stage IV disease patients. The 5‐year relative survival increased significantly from 53 to 62% for colon cancer and from 51 to 65% for rectal cancer. Ongoing advancements in treatment, and also improvement in other factors in the care of CRC patients—such as diagnostics, dedicated surgery and pre‐ and postoperative care—lead to a continuous improvement in the relative survival of CRC patients. The increasing incidence of CRC favors the implementation of the screening program, of which the effects should be monitored closely. What's new? To best inform new directions for cancer management, it's important to study historical trends. Here, the authors analyzed 25 years of data in The Netherlands on colorectal cancer incidence, treatment and survival. During the period from 1989 to 2014, both incidence and 5‐year relative survival increased. Certain treatments also became more common, such as postoperative chemotherapy for Stage III patients and systemic therapy and surgical removal of metastases for Stage IV patients. Improved diagnostics and treatments have helped more patients survive, and the rising incidence of CRC supports the use of the nationwide screening program, introduced by the Dutch government in 2014.
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影响因子：
3.8
作者：
Bokkerink, G. M. J.;Buijs, E. F. M.;de Wilt, J. H. W.
通讯作者：
de Wilt, J. H. W.
影响因子：
2.8
作者：
Joern, Fischer;Gunter, Hellmich;Sigmar, Stelzner
通讯作者：
Sigmar, Stelzner
影响因子：
39
作者：
Bretthauer M;Kaminski MF;Løberg M;Zauber AG;Regula J;Kuipers EJ;Hernán MA;McFadden E;Sunde A;Kalager M;Dekker E;Lansdorp-Vogelaar I;Garborg K;Rupinski M;Spaander MC;Bugajski M;Høie O;Stefansson T;Hoff G;Adami HO;Nordic-European Initiative on Colorectal Cancer (NordICC) Study Group
通讯作者：
Nordic-European Initiative on Colorectal Cancer (NordICC) Study Group
影响因子：
158.5
作者：
Kapiteijn, E;Marijnen, CAM;van de Velde, CJH
通讯作者：
van de Velde, CJH
影响因子：
45.3
作者：
Marijnen, CAM;Nagtegaal, ID;van Krieken, JHJM
通讯作者：
van Krieken, JHJM