Circadian rhythm of serum immunoreactive inhibin in young and elderly men.
Circadian rhythm of serum immunoreactive inhibin in young and elderly men.
复制标题
年轻和老年男性血清免疫反应性抑制素的昼夜节律。
DOI：
10.1093/geronj/46.5.m181
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Bremner,WJ
中科院分区：
文献类型：
--
作者：
Tenover,JS;Bremner,WJ
血清睾酮（T）水平和睾酮水平随着正常男性年龄的增长而下降。此外，在年轻男性中，血清T水平表现出昼夜变化，随着正常衰老而变钝或消失。本研究的目的是确定是否血清免疫反应性β-受体结合蛋白水平也表现出昼夜变化的年轻男性，如果正常老化的24小时血清β-受体结合蛋白模式的影响。从7名年轻（年龄25-35岁）和7名老年（年龄65-72岁）健康男性中每小时采集血样24小时。用放射免疫法测定血清睾酮和睾酮水平。与T类似，年轻男性的血清中的Tubin水平表现出昼夜节律模式。老年男性也表现出昼夜节律的血清β-氨基丁酸，平均幅度是没有显着不同的年轻男性，尽管事实上，平均24小时β-氨基丁酸水平的老年男性显着低于年轻男性。这些结果表明，免疫反应性β-胆固醇，像T，显示在成年男性的血清中的昼夜节律和β-胆固醇的生物节律在老年男性中保持。
Serum testosterone (T) levels and inhibin levels decline with normal male aging. In addition, in young men, serum T levels demonstrate a circadian variation that is blunted or lost with normal aging. The purpose of this study was to determine whether serum immunoreactive inhibin levels also demonstrate a circadian variation in young men and if normal aging has an effect on the 24 hr serum inhibin pattern. Hourly blood samples were obtained for 24 hr from 7 young (age 25-35 yr) and 7 elderly (age 65-72 yr) healthy men. Serum inhibin and testosterone levels were measured by RIA. Similar to T, serum inhibin levels demonstrated a circadian pattern in young men. Elderly men also demonstrated a circadian rhythm in serum inhibin, with an average amplitude that was not significantly different from that found in young men, despite the fact that the average 24-hr inhibin level in the elderly men was significantly lower than in the young men. These results demonstrate that immunoreactive inhibin, like T, displays a circadian rhythm in the serum of adult men and the inhibin biorhythm is maintained in elderly men.