Techno-economic assessment of bioethanol production from lignocellulose by consortium-based consolidated bioprocessing at industrial scale
Techno-economic assessment of bioethanol production from lignocellulose by consortium-based consolidated bioprocessing at industrial scale
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DOI：
10.1016/j.nbt.2021.07.005
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发表时间：
2021-08-19
影响因子：
5.4
通讯作者：
Studer, Michael Hans-Peter
中科院分区：
文献类型：
--
作者：
Dempfle, David;Krocher, Oliver;Studer, Michael Hans-Peter
以木质纤维素为基础的生物燃料对于减轻国际交通运输对气候变化的影响，同时维持农业用地的粮食供应至关重要。高度集成的系统，如联合生物处理（CBP），其中酶的生产，酶水解和释放的糖发酵在一个反应器中进行，提供了最大的潜力，以节省成本，并使木质纤维素生物燃料具有经济竞争力。本文所述的工作表明，与传统的从木质纤维素生产乙醇相比，在全规模（2000 t/d）下操作的基于微生物聚生体的CBP在单个工艺步骤中节省高达27.5%的总乙醇生产成本。成本节约主要是通过降低CAPEX实现的，这是由于集成过程导致的设备需求减少，以及通过降低OPEX实现的，因为酶生产不需要葡萄糖。与文献估计的成本节约CBP的基础上转基因微生物的结果在大致相同的范围。作为详细的敏感性分析的结果，从工艺角度来看，规模和产量被确定为主要的成本推动因素，而工厂位置的价格水平对投资条件的影响最大。在欧盟，CBP产生了足够的利润，用于有利可图的生产和分散生物质价值的可能性，而在世界上最大的乙醇市场，美国，木质纤维素乙醇的有利可图的生产只能通过CBP与其他节省成本的技术相结合来实现，例如利用无成本的废物原料，因为乙醇已经经历了相当大的价格暴跌。
Lignocellulose-based biofuels are of major importance to mitigate the impact of international traffic and transport on climate change while sustaining agricultural land for food supply. Highly integrated systems like consolidated bioprocessing (CBP), where enzyme production, enzymatic hydrolysis and fermentation of the released sugars are carried out in one reactor, offer the highest potential to save costs and to make lignocellulosebased biofuels economically competitive. The work described here showed that CBP based on a microbial consortium operated at full-scale (2000 t/d) saves up to 27.5 % of the total ethanol production costs compared to conventional ethanol production from lignocellulose in individual process steps. The cost savings are mainly achieved through lower CAPEX due to less apparatus requirements because of the integrated process, as well as through lower OPEX since no glucose is needed for enzyme production. A comparison with literature estimations of cost savings of CBP based on genetically modified microorganisms results in approximately the same range. As a result of a detailed sensitivity analysis, scale and yield were identified as the main cost-pushers from a process point of view, whereas the price level of the plant location has the highest impact on the investment conditions. In the EU, CBP yields enough margin for profitable production and the possibility to decentralize biomass valorization, whereas in the world's largest ethanol market, the U.S, profitable production of lignocellulosic ethanol can only be achieved by CBP combined with other cost saving techniques, such as utilization of cost-free waste feedstocks, since ethanol has undergone a considerable price slump.