The Neurobiological Basis for Social Affiliation in Autism Spectrum Disorder and Schizophrenia.
The Neurobiological Basis for Social Affiliation in Autism Spectrum Disorder and Schizophrenia.
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DOI：
10.1007/s40473-016-0079-0
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发表时间：
2016-06
影响因子：
1.7
通讯作者：
中科院分区：
文献类型：
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社交互动和沟通是复杂的行为范式，涉及许多组成部分。许多不同的神经递质、激素、感觉输入和大脑区域都参与社会参与和言语或非言语交流的行为。自闭症谱系障碍 (ASD) 和精神分裂症是两种神经发育障碍，以社交和语言缺陷为标志症状，但病因却截然不同。自闭症谱系障碍和精神分裂症都会产生社交功能障碍，但这可能是由非常不同的病理生理学手段引起的。本综述将尝试编译和解释人类和动物研究，这些研究显示自闭症谱系障碍和精神分裂症社交和语言缺陷发展的神经生物学基础，并对这两种疾病进行比较。
Social interaction and communication are complex behavioral paradigms involving many components. Many different neurotransmitters, hormones, sensory inputs, and brain regions are involved in the act of social engagement and verbal or nonverbal communication. Autism Spectrum Disorder (ASD) and schizophrenia are two neurodevelopmental disorders that have social and language deficits as hallmark symptoms, but show very different etiologies. The output of social dysfunction is common to both ASD and schizophrenia, but this likely arises from very different pathophysiological means. This review will attempt to compile and interpret human and animal studies showing the neurobiological basis for the development of social and language deficits in ASD and schizophrenia as well as a comparison of the two disorders.