Allergic conjunctivitis in children with asthma, rhinitis and eczema in a secondary outpatient clinic
Allergic conjunctivitis in children with asthma, rhinitis and eczema in a secondary outpatient clinic
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DOI：
10.1111/j.1399-3038.2006.00429.x
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发表时间：
2006-11-01
影响因子：
4.4
通讯作者：
Wolthers, Ole D.
中科院分区：
文献类型：
--
作者：
Gradman, Josefine;Wolthers, Ole D.
关于过敏性结膜炎在儿科人群中的患病率的证据很少。本研究的目的是评估在二级儿科门诊患有鼻炎、哮喘和湿疹的儿童中过敏性结膜炎的累积患病率。在2002-2004年期间被诊断为过敏性结膜炎、哮喘、过敏性鼻炎或湿疹的5-15岁儿童被纳入一项回顾性调查。转诊时，将患者特征、病史、症状、体征和1型过敏试验结果输入电子表格。458名平均年龄为9.4岁的儿童进行了研究。在316、324和149名鼻炎、哮喘和湿疹患儿中，分别有133名（42%）、78名（24%）和45名（30%）伴有过敏性结膜炎。137人（30%）患有过敏性结膜炎，其中133人（97%）还患有过敏性鼻炎、77人（56%）患有哮喘和45人（33%）患有湿疹。125例（91%）过敏性结膜炎儿童对一种或多种过敏原的过敏试验呈阳性，慢性过敏性结膜炎对屋尘螨的致敏率高于急性过敏性结膜炎（95% vs. 53%; p < 0.01）。急性过敏性结膜炎儿童对草的敏感性更高（78% vs. 57%; p = 0.03）。在二级儿科门诊中，过敏性结膜炎是过敏性鼻炎、哮喘和湿疹的常见并发症。过敏性结膜炎需要作为一个重要的合并症纳入未来的哮喘，鼻炎和湿疹管理指南。
Little evidence is available on the prevalence of allergic conjunctivitis in pediatric populations. The objective of this study was to assess the cumulative prevalence of allergic conjunctivitis in children with rhinitis, asthma and eczema in a secondary pediatric outpatient clinic. Children aged 5-15 yr referred during the period of 2002-2004 in whom allergic conjunctivitis, asthma, allergic rhinitis or eczema was diagnosed were included in a retrospective survey. At referral patient characteristics, history, symptoms, signs and results of type 1 allergy tests were entered into an electronic form. Four hundred and fifty-eight children with a mean age of 9.4 yr were studied. Of 316, 324 and 149 children with rhinitis, asthma or eczema, respectively, 133 (42%), 78 (24%) and 45 (30%) had concomitant allergic conjunctivitis. One hundred and thirty-seven (30%) had allergic conjunctivitis, of whom 133 (97%) also had allergic rhinitis, 77 (56%) asthma and 45 (33%) eczema. One hundred and twenty-five (91%) of the children with allergic conjunctivitis had positive allergy tests to one or more allergens, sensitization to house dust mites being more frequent in chronic allergic conjunctivitis than in acute allergic conjunctivitis (95% vs. 53%; p < 0.01). Sensitization to grass was more frequent in children with acute allergic conjunctivitis (78% vs. 57%; p = 0.03). In a secondary pediatric outpatient clinic allergic conjunctivitis is a frequent co-morbidity to allergic rhinitis and to asthma and eczema. Allergic conjunctivitis need to be included as an important co-morbidity in future guidelines on asthma, rhinitis and eczema management.