The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies
The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies
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DOI：
10.1016/j.joca.2008.09.013
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发表时间：
2009-06-01
影响因子：
7
通讯作者：
Felson, D. T.
中科院分区：
文献类型：
--
作者：
Roemer, F. W.;Guermazi, A.;Felson, D. T.
目的：通过磁共振成像 (MRI) 评估无放射骨关节炎 (OA) 的膝关节半月板状态与关节积液之间的横断面关联。设计：通过 MRI 检查来自 Framingham 和 MOST 研究的无 OA 膝关节（Kellgren/Lawrence 0 级）。半月板状态用内侧/外侧半月板的前角/体/后角的0-4分来评估，积液用0-3的分数来评估。使用逻辑回归模型估计半月板损伤患者关节积液的比值比 (OR)。对 MRI 未检测到软骨损伤的膝关节进行了子分析。结果：在 1368 个膝关节中，296 个膝关节 (21.6%) 至少在一个分区出现半月板病变。半月板损伤的膝关节中有 133 例（44.9%）出现积液，而没有半月板损伤的膝关节有 328 例（30.6%）出现积液。半月板损伤膝关节积液的调整 OR 为 1.8，95% 置信区间 (CI) [1.4，2.4]。两个半月板病变组的积液 OR 为 5.4，95% CI [2.1，14.3]。对于没有任何软骨损伤但任何部位有半月板损伤的膝关节，OR 为 2.3，95% CI [1.1，4.5]。结论：没有 OA 但有半月板病变的膝关节表现出关节积液的程度明显高于没有半月板损伤的膝关节。对于没有软骨损伤的膝盖，这种关联仍然存在。当存在于两个隔室中时，积液的发生率进一步增加。滑膜激活和半月板损伤的同时发生有助于了解早期退行性关节疾病的病理生理学。 (C) 2008 年国际骨关节炎研究协会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To assess the cross-sectional association between meniscal status and joint effusion on magnetic resonance imaging (MRI) in knees without radiographic osteoarthritis (OA).Design: Knees without OA (Kellgren/Lawrence grade 0) from the Framingham and MOST studies were examined by MRI. Meniscal status was assessed with a score of 0-4 in the anterior horn/body/posterior horn of the medial/lateral meniscus and effusion was assessed using a score of 0-3. The odds ratios (ORs) of joint effusion in those with meniscal damage were estimated using a logistic regression model. A sub-analysis was performed for knees without MRI-detected cartilage damage.Results: Of 1368 knees, 296 (21.6%) showed meniscal pathology in at least one subregion. Effusion was present in 133 (44.9%) of knees with meniscal damage vs 328 (30.6%) in those without meniscal damage. The adjusted OR of effusion in a knee with meniscal damage was 1.8, 95% confidence intervals (CI) [1.4, 2.4]. The OR of effusion for the group with meniscal pathology in two compartments was 5.4, 95% CI [2.1, 14.3]. For knees without any cartilage lesions but with meniscal damage in any compartment the OR was 2.3, 95% CI [1.1, 4.5].Conclusions: Knees without OA but with meniscal pathology exhibit joint effusion to a significantly higher degree than knees without meniscal damage. The association persists for knees without cartilage damage. The prevalence of effusion is further increased when present in two compartments. Concomitant occurrence of synovial activation and meniscal damage contributes to understanding the pathophysiology of early degenerative joint disease. (C) 2008 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.