The origin of embryonic and fetal myoblasts: a role of Pax3 and Pax7
The origin of embryonic and fetal myoblasts: a role of Pax3 and Pax7
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DOI：
10.1101/gad.1797009
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发表时间：
2009-04-15
影响因子：
10.5
通讯作者：
Cossu, Giulio
中科院分区：
文献类型：
--
作者：
Messina, Graziella;Cossu, Giulio
骨骼肌是由单个肌纤维组成的异质组织，其大小、形状和收缩蛋白含量多样化，以满足脊椎动物身体的不同功能需求。这种异质性源自并至少部分取决于肌源性祖细胞的不同类别。即胚胎和胎儿成肌细胞和卫星细胞，其起源和谱系关系迄今为止仍难以捉摸。在本期《基因与发育》中，Hutcheson 及其同事（第 997-1013 页）对此问题提供了第一个答案。
Skeletal muscle is a heterogeneous tissue composed of individual muscle fibers, diversified in size, shape, and contractile protein content, to fulfill the different functional needs of the vertebrate body. This heterogeneity derives from and depends at least in part on distinct classes of myogenic progenitors; i.e., embryonic and fetal myoblasts and satellite cells whose origin and lineage relationship have been elusive so far. In this issue of Genes & Development, Hutcheson and colleagues (pp. 997-1013) provide a first answer to this question.