Cardiovascular response during head-up tilt in chronic fatigue syndrome.
Cardiovascular response during head-up tilt in chronic fatigue syndrome.
复制标题
慢性疲劳综合症抬头倾斜期间的心血管反应。
DOI：
10.1046/j.1365-2281.1999.00154.x
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Natelson,BH
中科院分区：
文献类型：
--
作者：
LaManca,JJ;Peckerman,A;Walker,J;Kesil,W;Cook,S;Taylor,A;Natelson,BH
This study examined the cardiovascular response to orthostatic challenge, and incidence and mechanisms of neurally mediated hypotension in chronic fatigue syndrome (CFS) during a head‐up tilt test. Stoke volume was obtained by a thoracic impedance cardiograph, and continuous heart rate and blood pressure were recorded during a 45‐min 70° head‐up tilt test. Thirty‐nine CFS patients and 31 healthy physically inactive control subjects were studied. A positive tilt, i.e. a drop in systolic blood pressure openface> 25 mmHg, no concurrent increase in heart rate and/or development of presyncopal symptoms, was seen in 11 CFS patients and 12 control subjects (P>0·05). During baseline and the first 5 min of head‐up tilt, CFS patients had higher heart rate and smaller pulsatile‐systolic area than control subjects (P<0·05). Among subjects who completed the test, those with CFS had higher heart rate and smaller stroke volume (P<0·05) than corresponding control subjects. When comparing those who had a positive test outcome in each group, CFS patients had higher heart rates and lower pulse pressure and pulsatile‐systolic areas during the last 4 min before being returned to supine (P<0·05). These data show that there are baseline differences in the cardiovascular profiles of CFS patients when compared with control subjects and that this profile is maintained during head‐up tilt. However, the frequency of positive tilts and the haemodynamic adjustments made to this orthostatic challenge are not different between groups.
