Ditterential effects of spontaneous versus forced exercise in rats on the staining of parvalbumin-positive neurons in the hippocampal formation
Ditterential effects of spontaneous versus forced exercise in rats on the staining of parvalbumin-positive neurons in the hippocampal formation
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DOI：
10.1016/j.neulet.2004.03.086
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发表时间：
2004-07-08
影响因子：
2.5
通讯作者：
Cavalheiro, EA
中科院分区：
文献类型：
--
作者：
Arida, RM;Scorza, CA;Cavalheiro, EA
要调查是否类型的体力活动，自愿或被迫，将促进不同的形态学变化，在海马结构中，我们进行了免疫细胞化学研究使用的小白蛋白（PV）的分布作为标记。将接受自愿运动的动物置于自愿轮跑中，将接受强制运动的动物置于电机驱动的跑步机中。两个运动组都进行了连续10天的体力活动。与对照组相比，在自愿和强迫运动组中观察到更多的PV阳性细胞在齿状回（DG）门中。自愿运动组也提出了更强的纤维染色在DG门比强迫运动组和对照组。相反，运动组和对照组之间在CA 1/CA 3区域的PV染色模式没有发现差异。这些发现表明，体力活动导致大鼠海马结构的显著塑性变化，在自愿活动后更明显。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
To investigate whether the type of physical activity, voluntary or forced, would promote different morphological changes in hippocampal formation we performed an immunocytochemical study using the parvalbumin (PV) distribution as a marker. Animals submitted to the voluntary exercise were placed in a voluntary wheel running and those submitted to the forced exercise were placed in a motor driven treadmill. Both exercise groups were submitted to 10 consecutive days of physical activity. It was observed a higher number of PV-positive cells in the hilus of dentate gyrus (DG) in the voluntary and forced exercise groups when compared to the control group. The voluntary exercise group also presented a stronger fiber staining in the DG hilus than the forced exercise and control groups. In contrast, no differences were found in the pattern of PV staining in CA1/CA3 region between exercise and control groups. These findings demonstrate that physical activity leads to prominent plastic changes in the hippocampal formation of rats that were more evident following voluntary activity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.