EFFECT OF INTRAVENOUS ADMINISTRATION OF APOLIPOPROTEIN A-IV ON PATTERNS OF FEEDING, DRINKING AND AMBULATORY ACTIVITY OF RATS
EFFECT OF INTRAVENOUS ADMINISTRATION OF APOLIPOPROTEIN A-IV ON PATTERNS OF FEEDING, DRINKING AND AMBULATORY ACTIVITY OF RATS
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DOI：
10.1016/0006-8993(93)91463-3
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发表时间：
1993-04-16
期刊：
影响因子：
2.9
通讯作者：
TSO, P
中科院分区：
文献类型：
--
作者：
FUJIMOTO, K;MACHIDORI, H;TSO, P
为了表征载脂蛋白A-IV（apo A-IV）的厌食作用，我们研究了apo A-IV对自由进食大鼠的进食、饮水和排便模式的影响。在黑暗期之前，通过长期留置的右心房导管静脉输注单剂量200、135或60 μ g。Apo A-IV通过减少膳食量来抑制摄食，但不影响两餐之间的间隔、进食速度或输注后进食第一餐的潜伏期。apo A-IV的厌食作用呈剂量依赖性，输注后约3 h有效。apo A-IV的厌食作用是特异性的，因为apo A-IV的失活消除了其厌食作用。apo A-IV的减食欲作用与apo A-I不同。载脂蛋白A-IV对饮酒行为或步行活动没有影响。结果似乎表明，载脂蛋白A-IV具体减少膳食的大小，这支持我们的假设，载脂蛋白A-IV可能作为一个生理信号，饱食后摄入的脂质餐。
To characterize the anorectic effect of apolipoprotein A-IV (apo A-IV), we examined the effect of apo A-IV on the patterns of feeding, drinking and ambulation of rats fed ad libitum. A single dose of 200, 135 or 60 mug was infused intravenously through a chronically indwelling right atrial catheter just before the dark period. Apo A-IV suppressed food intake by decreasing meal size, but did not affect the interval between meals, the speed of eating, or the latency to eat the first meal after infusion. The anorectic effect of apo A-IV was dose-dependent and was effective for about 3 h after the infusion. The anorectic effect of apo A-IV is specific because inactivation of apo A-IV abolishes its anorectic effect. The anorectic effect of apo A-IV is not shared by apo A-I. Apo A-IV had no effect on drinking behavior or ambulatory activity. The results seem to indicate that apo A-IV specifically decreases the meal size, which supports our hypothesis that apo A-IV may act as a physiological signal for satiation after the ingestion of a lipid meal.