A direct measurement for LDL-cholesterol increases hypercholesterolemia prevalence: comparison with Friedewald calculation.
A direct measurement for LDL-cholesterol increases hypercholesterolemia prevalence: comparison with Friedewald calculation.
复制标题
直接测量 LDL 胆固醇会增加高胆固醇血症患病率：与 Friedewald 计算的比较。
DOI：
10.7888/juoeh.32.211
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Y. Otsuji
中科院分区：
文献类型：
--
作者：
F. Kamezaki;S. Sonoda;Sei Nakata;Y. Otsuji
均相直接测定法最近已被应用于低密度脂蛋白-胆固醇(LDL-C)的测定，并在日本取代了Friedewald计算法，但在评估高胆固醇血症方面，直接测定法与Friedewald计算法的比较尚不清楚。本研究的目的是确定这两种方法在高胆固醇血症诊断中的作用。用直接法和Friedewald法测定了1655名工作人员(男性1451人，年龄43.6±10.2岁；女性204人，年龄38.3±10.4岁)的低密度脂蛋白-C水平。在这项研究中，我们排除了甘油三酯水平超过400 mg/dl的工人(n=18)。直接低密度脂蛋白与弗里德瓦尔德低密度脂蛋白呈显著正相关(R2=0.975，P<；0.0001)。另一方面，直接低密度脂蛋白胆固醇的平均值为5.9 mg/dl，高于弗里德瓦尔德低密度脂蛋白胆固醇平均值(126.7±30.6 mg/dl比120.8±30.5 mg/dl，P<；0.0001)，89.1%的研究人群的直接低密度脂蛋白胆固醇水平较高。直接测量的研究对象被诊断为高胆固醇血症的频率(定义为低密度脂蛋白或=140mgdl)明显高于弗里德瓦尔德计算(31.7%vs.25.1%，P<；0.0001)。总而言之，我们证明，直接测量显示的高胆固醇血症患病率比Friedewald计算显示的更高。提示在高胆固醇血症的临床诊断和治疗决策中，应慎重考虑低密度脂蛋白胆固醇的检测方法。
Direct measurement by homogenous assays has recently been applied to measuring low-density lipoprotein-cholesterol (LDL-C) and has replaced the Friedewald calculation in Japan, but it remains unclear how direct measurement compares with the Friedewald calculation in evaluating hypercholesterolemia. The aim of this study was to determine the effect of the two methods on the diagnosis of hypercholesterolemia. In a total of 1655 workers from our institution (1451 men, 43.6 +/- 10.2 years; 204 women, 38.3 +/- 10.4 years), we investigated the LDL-C levels by the direct and Friedewald methods. In this study, we excluded workers whose triglyceride levels exceeded 400 mg/dl (n=18). Direct LDL-C showed a significantly positive correlation with Friedewald LDL-C (R2 = 0.975, P < 0.0001). On the other hand, the mean direct LDL-C was 5.9 mg/dl higher than the mean Friedewald LDL-C (126.7 +/- 30.6 mg/dl vs. 120.8 +/- 30.5 mg/dl, P < 0.0001), and direct LDL-C was higher in 89.1% of the study population. The frequency of study subjects diagnosed with hypercholesterolemia, defined as LDL-C > or =140 mg/dl, was significantly higher in the direct measurement than in the Friedewald calculation (31.7% vs. 25.1%, P < 0.0001). In conclusion, we demonstrated that the direct measurement showed a higher rate of hypercholesterolemia prevalence than the Friedewald calculation indicated. This result suggests that we have to give careful consideration to the method for measuring LDL-C in the clinical diagnosis and management decisions of hypercholesterolemia.
通过 Friedewald 方程估算低密度脂蛋白胆固醇足以根据国家推荐的切点对患者进行分类。
影响因子：
9.3
作者：
Warnick,GR;Knopp,RH;Fitzpatrick,V;Branson,L
通讯作者：
Branson,L