Comparison of Foveal Microstructure Imaging with Different Spectral Domain Optical Coherence Tomography Machines
Comparison of Foveal Microstructure Imaging with Different Spectral Domain Optical Coherence Tomography Machines
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DOI：
10.1016/j.ophtha.2012.07.012
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发表时间：
2012-11-01
期刊：
影响因子：
13.7
通讯作者：
Sakamoto, Taiji
中科院分区：
文献类型：
--
作者：
Terasaki, Hiroto;Shirasawa, Makoto;Sakamoto, Taiji
目的：探讨三种光谱域光学相干断层成像（SD-OCT）机器：Cirrus （Carl Zeiss Meditec Inc.）、Spectralis （Heidelberg Engineering）和Topcon （Topcon 3D OCT-1000 Mark II）对健康眼睛中央凹微结构成像的可重复性。设计：横断面、前瞻性、非介入性研究。参与者：在临床环境中获得50名健康未扩张志愿者的50只眼睛的图像。方法：采用Cirrus、Spectralis和Topcon对所有受试者的中央窝进行成像。主要观察指标：SD-OCT成像外中央窝下4条高反射带中，最内层带（外限制膜[ELM]带）、最内层第二带（第二带）、最内层第三带（第三带）被2位独立评分者分类为“连续”、“中断”或“无”。加权β系数分析和/或Fisher精确检验用于比较机器间、机器间和机器内的一致性测量。并对每台机器的灵敏度进行了评价。结果：本组50例患者，男22例，女28例，平均年龄31.4岁（21 ~ 52岁）。Cirrus、Spectralis和Topcon在3个波段的一致性较高（kappa分别为0.876、0.738和0.774）。每台机器对卷云、Spectralis和Topcon的ELM波段（0.92、0.98和0.96）、第二波段（均为1.00）和第三波段（0.96、0.94和0.88）的灵敏度都很高。Topcon对第三波段的灵敏度显著低于第二波段（Fisher精确检验，P = 0.027），但与其他机器的差异不显著。在Cirrus-Spectralis、Spectralis-Topcon和Topcon-Cirrus之间，第三波段（kappa = 0.65、0.512和0.464）和所有波段（kappa = 0.531、0.369和0.362）的机器间一致性为中等到中等；而Spectralis-Topcon在ELM波段上差异不显著（kappa = -0.027）。结论：在视力正常的健康成人中，使用Cirrus、Spectralis和Topcon装置获得的中央凹显微结构图像在评分者之间几乎具有完美的再现性。机器对图像中央凹微结构具有良好的灵敏度，不同机器对图像中央凹微结构的灵敏度差异不显著；然而，它们并不一定是相同的或可互换成像某些结构。财务披露：作者在本文中讨论的任何材料中没有专有或商业利益。眼科2012;119:2319-2327 (C) 2012由美国眼科学会。
Purpose: To investigate the reproducibility of imaging the foveal microstructures of healthy eyes with 3 spectral domain optical coherence tomography (SD-OCT) machines: Cirrus (Carl Zeiss Meditec Inc.), Spectralis (Heidelberg Engineering), and Topcon (Topcon 3D OCT-1000 Mark II).Design: Cross-sectional, prospective, noninterventional study.Participants: Images were obtained for 50 eyes of 50 healthy undilated volunteers without ocular pathology in a clinical setting.Methods: The fovea of all subjects was imaged using Cirrus, Spectralis, and Topcon.Main Outcome Measures: Among the 4 hyperreflective bands in the outer subfovea on SD-OCT imaging, the innermost band (external limiting membrane [ELM] band), the second innermost band (second band), and the third innermost band (third band) were classified as "continuous," " disrupted," or "none" by 2 independent raters. Weighted beta-coefficient analysis and/or Fisher exact test were used to compare interrater, intermachine, and intramachine agreement measurements. The sensitivity of each machine was also evaluated.Results: The group of 50 subjects consisted of 22 men and 28 women, with an average age of 31.4 years (range, 21-52 years). Interrater agreement for 3 bands was high (kappa = 0.876, 0.738, and 0.774) with Cirrus, Spectralis, and Topcon, respectively. The sensitivity of each machine was high for the ELM band (0.92, 0.98, and 0.96), the second band (all 1.00), and the third band (0.96, 0.94, and 0.88) with Cirrus, Spectralis, and Topcon, respectively. The sensitivity of the third band was significantly lower than the second band with Topcon (Fisher exact test, P = 0.027), but the difference was not significant with the other machines. Intermachine agreement was fair to moderate for the third band (kappa = 0.65, 0.512, and 0.464) and for all bands (kappa = 0.531, 0.369, and 0.362) between Cirrus-Spectralis, Spectralis-Topcon, and Topcon-Cirrus, respectively; however, it was not significant for ELM band (kappa = -0.027) between Spectralis-Topcon.Conclusions: In healthy adults with normal vision, there was almost perfect reproducibility between raters for foveal microstructural images acquired with the Cirrus, Spectralis, and Topcon devices. The machines have good sensitivity to image foveal microstructures, and the sensitivity does not differ significantly among machines; however, they are not necessarily identical or interchangeable for imaging certain structures.Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article. Ophthalmology 2012;119:2319-2327 (C) 2012 by the American Academy of Ophthalmology.