Obstructive sleep apnoea is associated with risk factors comprising the metabolic syndrome
Obstructive sleep apnoea is associated with risk factors comprising the metabolic syndrome
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DOI：
10.1111/j.1440-1843.2010.01818.x
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发表时间：
2010-10-01
期刊：
影响因子：
6.9
通讯作者：
Hashimoto, Shu
中科院分区：
文献类型：
--
作者：
Akahoshi, Toshiki;Uematsu, Akihito;Hashimoto, Shu
背景与目的：OSA综合征的几个特征提示它是代谢综合征（MS）的一种表现。在这项研究中，我们调查了日本男性OSA患者中MS的患病率，以及非肥胖患者的OSA与肥胖以外的MS组成（高血压、血脂异常和葡萄糖耐受不良）之间的关系。方法：研究对象为416名经多导睡眠图诊断为阻塞性睡眠呼吸暂停的日本男性。其中选取101例非肥胖患者，评估OSA严重程度、高血压、血脂异常、葡萄糖耐受不良的患病率。结果：416例患者中有218例（52.4%）合并阻塞性睡眠呼吸暂停。根据AHI分类，MS患病率的显著增加与OSA严重程度的增加相关。在非肥胖OSA患者（平均年龄57.6岁，BMI 22.7 kg/m(2), AHI 34.3事件/h）中，分别有70例（69.3%）、43例（42.6%）和20例（19.8%）存在高血压、血脂异常和葡萄糖耐受不良。在40例（39.6%）患者中至少发现了上述两种因素。非肥胖严重OSA患者在上述两种或两种以上因素中的患病率明显较高（33/59例，55.9%）。结论：虽然亚洲人的肥胖程度普遍低于白种人，但日本OSA患者的MS患病率较高，即使在非肥胖患者中，OSA也与MS的危险因素相关。
Background and objective: Several features of OSA syndrome suggest that it is a manifestation of the metabolic syndrome (MS). In this study, we investigated the prevalence of the MS among male Japanese patients with OSA, as well as the relationship between OSA in non-obese patients and components of the MS other than obesity (hypertension, dyslipidaemia and glucose intolerance).Methods: The study included 416 Japanese men who were diagnosed as having OSA by polysomnography. Among these, 101 non-obese patients were selected and the severity of OSA, as well as the prevalence of hypertension, dyslipidaemia and glucose intolerance, was assessed.Results: The MS was associated with OSA in 218/416 patients (52.4%). A significant increase in the prevalence of the MS was associated with increased severity of OSA, as categorized according to AHI. In the non-obese patients with OSA (mean age 57.6 years, BMI 22.7 kg/m(2), AHI 34.3 events/h), hypertension, dyslipidaemia and glucose intolerance were identified in 70 (69.3%), 43 (42.6%) and 20 patients (19.8%), respectively. At least two of these factors were identified in 40 patients (39.6%). Non-obese patients with severe OSA had a significantly higher prevalence of two or more of these factors (33/59 patients, 55.9%).Conclusions: Although Asians are generally less obese than Caucasians, the prevalence of the MS was high among Japanese patients with OSA, and even among non-obese patients, OSA was associated with risk factors for the MS.