Concentration recovery for SPECT CNS dopamine-receptor studies for monkeys.
Concentration recovery for SPECT CNS dopamine-receptor studies for monkeys.
复制标题
猴子 SPECT CNS 多巴胺受体研究的浓度回收。
DOI：
10.1118/1.597321
复制
发表时间：
1994
期刊：
影响因子：
3.8
通讯作者：
Kung,HF
中科院分区：
文献类型：
--
作者：
Shao,L;Billings,J;Pfeiffer,N;Kung,HF
大多数商业SPECT扫描仪不能正确补偿散射和部分体积效应，这严重影响了临床和研究SPECT研究的定量，特别是在CNS多巴胺研究中。因此，在本文中，包含猴头骨的脑体模被用于校准Picker Prism 3000 SPECT相机，用于123 I和99 mTc标记的放射性药物的定量研究。在校准研究中，将代表基底神经节的两个小瓶插入颅骨体模中。在基底节和其他脑区室之间以不同的浓度比拍摄一系列图像，以模拟猴脑中多巴胺D2受体的动态成像研究。在此基础上，提出了一种简单的感兴趣区域（ROI）计数校正方法。该技术上级于使用来自圆柱形均匀放射性体模的单个校准因子，因为它可以补偿部分体积效应和散射的动态变化效应。在校正因子中观察到真实值和测量值之间的显著差异（因子高达3）。此外，一个圆柱体模，大约一个猴子的头部的大小，并包含相同的基底神经节插入，被用来调查的可行性，使用圆柱体模与建议的校正方法。结果表明，对于脑腔内活动与周围组织活动相似的情况，使用圆柱体模是可行的。
Most commercial SPECT scanners do not properly compensate for scattering and partial volume effects, which severely impacts the quantitation of clinical and research SPECT studies, especially in CNS dopamine studies. Hence, in this paper, a brain phantom containing a monkey skull was used to calibrate a Picker Prism 3000 SPECT camera for quantitative studies of123I and99mTc‐labeled radiopharmaceuticals. In the calibration study, two small vials representing basal ganglia were inserted into a skull phantom. A series of images were taken with different concentration ratios between the basal ganglia and the other brain compartments to simulate the dynamic imaging study of the dopamineD2 receptor in a monkey brain. Based on this calibration, a simple method is proposed for count correction in the region of interest (ROI). This technique is superior to using a single calibration factor from a cylindrical uniform activity phantom since it can compensate for both the partial volume effect and the dynamically changing effect of scattering. A significant difference between the true and measured values was observed in the correction factors (by a factor as much as 3). Furthermore, a cylindrical phantom, approximately the size of a monkey's head and containing the same basal ganglia inserts, was used to investigate the feasibility of using a cylindrical phantom with the proposed correction method. The results indicate that it is feasible to use a cylindrical phantom for the case where the activity inside the brain cavity and the activity in the surrounding tissue are similar.